Analgesia & Resuscitation : Current ResearchISSN: 2324-903X

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Research Article, Analg Resusc Curr Res S Vol: 2 Issue: 0

Effect of Neuromuscular Blockers on Outcomes in Patients Receiving Therapeutic Hypothermia Following Cardiac Arrest

William L Baker1,2,3*, Giovanni Geronila4, Ranya Kallur4, Adam Noyes4, Lindsay Smyth1, John T Stiles1, Kelley N Sawyer5 and Justin B Lundbye2,4,6
1A1University of Connecticut School of Pharmacy, Storrs and Farmington, CT, USA
2University of Connecticut School of Medicine, Storrs and Farmington, CT, USA
3Division of Drug Information, Hartford Hospital, Hartford, CT, USA
4Division of Cardiology, Hartford Hospital, Hartford, CT, USA
5Department of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, USA
6Division of Cardiology, Hospital of Central Connecticut, New Britain, CT, USA
Corresponding author : William L Baker, Pharm.D., BCPS (AQ Cardiology)
Assistant Professor of Pharmacy and Medicine, University of Connecticut, Schools of Pharmacy and Medicine, 263 Farmington Ave, MC2205, Farmington, CT 06033, USA
Tel: 860-679-3889; Fax: 860-545-2277
E-mail: [email protected]
Received: April 05, 2013 Accepted: May 30, 2013 Published: June 07, 2013
Citation: Baker WL, Geronila G, Kallur R, Noyes A, Smyth L, et al. (2013) Effect of Neuromuscular Blockers on Outcomes in Patients Receiving Therapeutic Hypothermia Following Cardiac Arrest Analg Resusc: Curr Res S1. doi:10.4172/2324-903X.S1-001

Abstract

Effect of Neuromuscular Blockers on Outcomes in Patients Receiving Therapeutic Hypothermia Following Cardiac Arrest

The use of mild therapeutic hypothermia therapy (MTH) for the preservation of neurological function and improvement in survival after cardiac arrest has been well established. Complications of MTH include electrolyte shifting, hypercoagulability, hyperglycemia, and seizures, among others. Additionally, the prevention of shivering is important as it can negate the beneficial effects of MTH through a variety of mechanisms. These include increased oxygen consumption, increased metabolic demands, and increases in intracranial pressure. Current guidelines and numerous clinical trial protocols recommend the use of sedatives and neuromuscular blockers (NMBs) to prevent shivering during initial cooling.

Keywords: Neuromuscular blockers; Therapeutic hypothermia

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