Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Editorial, J Liver Dis Transplant Vol: 4 Issue: 2

Endoplasmic Reticulum Stress in Drug-Induced Liver Injury and Liver Diseases: An Unlighted Novel Mechanism

Erkekoglu P*, Koçer-Gümü┼čel B, Elnour A and Bhagavathula AS
Department of Toxicology, Hacettepe University, 06100, Ankara, Turkey
Corresponding author : Pinar Erkekoglu
Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100, Ankara, Turkey
Tel: +90 312 305 21 78; Fax: +90 312 311 47 77
E-mail: [email protected]
Received: October 06, 2015 Accepted: October 08, 2015 Published: October 12, 2015
Citation: Erkekoglu P, Koçer-Gümüsel B, Elnour A, Bhagavathula AS (2015) Endoplasmic Reticulum Stress in Drug-Induced Liver Injury and Liver Diseases: An Unlighted Novel Mechanism. J Liver: Dis Transplant 4:2. doi:10.4172/2325-9612.1000e109

Abstract

The endoplasmic reticulum (ER) is a very important organelle in the eukaryotic cells. It has two types: rough endoplasmic reticulum (rough ER, RER) and smooth endoplasmic reticulum (smooth ER, SER). ER plays a vital role in many cellular processes such as secretory and membrane protein synthesis, folding, assembly, trafficking and post-modulation. The lumen of the ER contains the highest concentration of Ca2+ within the cell because of active transport of calcium ions by Ca2+ ATPases and it is a unique environment in which an incredible process of protein quality control checking is performed.

Keywords: Liver Injury; Endoplasmic Reticulum

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