Journal of Virology & Antiviral ResearchISSN: 2324-8955

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, J Virol Antivir Res Vol: 3 Issue: 3

Gastro-intestinal Involvement of Primary Varicella Zoster Virus Infection in a Renal Transplant Recipient

M.M.L. Kho1*, I. Noorlander1, W. Weimar1, M. van Agteren1, G.M.G.M. Verjans2, R.M. Verdijk3, A.A. van der Eijk2, N.M. van Besouw1
1Department of Internal Medicine – Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, the Netherlands
2Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
3Department of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands
Corresponding author : M.M.L. Kho
Erasmus Medical Center Department of Internal Medicine ,Nephrology and Transplantation, Room D-427, P.O. Box 20403000 CA Rotterdam, Netherlands
Tel: +31 17040704
E-mail: m.kho@erasmusmc.nl
Received: March 14, 2014 Accepted: October 03, 2014 Published: October 03, 2014
Citation: M.M.L. Kho et al. (2014) Gastro-intestinal Involvement of Primary Varicella Zoster Virus Infection in a Renal Transplant Recipient. J Virol Antivir Res 3:3. doi:10.4172/2324-8955.1000126

Abstract

Biopsy proven gastro-intestinal involvement of Varicella Zoster Virus (VZV) infection is rare and has not previously been reported in renal transplant recipients. This case report concerns a 65 year old, VZV seronegative, renal transplant recipient who presented with a non-vesicular rash and abdominal pain. Endoscopy revealed gastro-duodenal ulceration and in gastric biopsies VZV-DNA was detected by polymerase chain reaction assay. We conclude that abdominal pain in the absence of vesicular skin lesions may be the presenting symptom of visceral VZV infection, a potentially life threatening disease. To diminish the risk of VZV infection, patients on the waiting list for transplantation who are VZV seronegative or have non-protective VZV-IgG antibody titers, it is advised to vaccinate for VZV prior to transplantation.

Keywords: Varicella zoster virus; Gastro-intestinal; Renal transplantation

international publisher, scitechnol, subscription journals, subscription, international, publisher, science

Track Your Manuscript

Awards Nomination

Media Partners

open access