Journal of Virology & Antiviral ResearchISSN: 2324-8955

Research Article, J Virol Antivir Res Vol: 3 Issue: 3

Gastro-intestinal Involvement of Primary Varicella Zoster Virus Infection in a Renal Transplant Recipient

M.M.L. Kho1*, I. Noorlander1, W. Weimar1, M. van Agteren1, G.M.G.M. Verjans2, R.M. Verdijk3, A.A. van der Eijk2, N.M. van Besouw1
1Department of Internal Medicine – Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, the Netherlands
2Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
3Department of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands
Corresponding author : M.M.L. Kho
Erasmus Medical Center Department of Internal Medicine ,Nephrology and Transplantation, Room D-427, P.O. Box 20403000 CA Rotterdam, Netherlands
Tel: +31 17040704
E-mail: [email protected]
Received: March 14, 2014 Accepted: October 03, 2014 Published: October 03, 2014
Citation: M.M.L. Kho et al. (2014) Gastro-intestinal Involvement of Primary Varicella Zoster Virus Infection in a Renal Transplant Recipient. J Virol Antivir Res 3:3. doi:10.4172/2324-8955.1000126

Abstract

Biopsy proven gastro-intestinal involvement of Varicella Zoster Virus (VZV) infection is rare and has not previously been reported in renal transplant recipients. This case report concerns a 65 year old, VZV seronegative, renal transplant recipient who presented with a non-vesicular rash and abdominal pain. Endoscopy revealed gastro-duodenal ulceration and in gastric biopsies VZV-DNA was detected by polymerase chain reaction assay. We conclude that abdominal pain in the absence of vesicular skin lesions may be the presenting symptom of visceral VZV infection, a potentially life threatening disease. To diminish the risk of VZV infection, patients on the waiting list for transplantation who are VZV seronegative or have non-protective VZV-IgG antibody titers, it is advised to vaccinate for VZV prior to transplantation.

Keywords: Varicella zoster virus; Gastro-intestinal; Renal transplantation

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