Journal of Veterinary Science & Medical Diagnosis ISSN: 2325-9590

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Research Article, J Vet Sci Med Diagn Vol: 4 Issue: 2

Gentamicin-induced Acute Kidney Injury in Equines is associated with Marked Acute Phase Response: An Experimental Study on Donkey (Equus asinus)

Maged El-Ashker1*, Engy Risha2, Fatma Abdelhamid2, Mohamed Salama3, Mahmoud El-Sebaei3 and Walaa Awadin4
1Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
2Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
3Department of Biochemistry, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
4Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
Corresponding author : Maged El-Ashker
Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
Tel: +2-050-6329195; Fax: +2-050-2379952
E-mail: [email protected]
Received: June 02, 2014 Accepted: September 03, 2014 Published: September 05, 2014
Citation: El-Ashker M, Risha E, Abdelhamid F, Salama M, El-Sebaei M et al. (2014) Gentamicin-induced Acute Kidney Injury in Equines is associated with Marked Acute Phase Response: An Experimental Study on Donkey (Equus asinus). J Vet Sci Med Diagn 4:2. doi:10.4172/2325-9590.1000154

Abstract

 Gentamicin-induced Acute Kidney Injury in Equines is associated with Marked Acute Phase Response: An Experimental Study on Donkey (Equus asinus)

Recently, there is growing evidence suggesting that acute kidney injury (AKI) in human and laboratory animals is associated with an inflammatory response that could play a role in tissue damage. However, such link has not previously been addressed in equines. The present study was designed to evaluate the effect of gentamicin (GEN) administration on the development of AKI and systemic inflammatory response in equines using donkey as a model. GEN (10%) was administered intravenously in six donkeys at a dose of 20 mg kg-1 BW thrice daily for 14 consecutive days. Three other donkeys were randomly assigned to receive saline solution and served as controls. The donkeys were clinically and sonographically examined throughout the experimental period. Blood and urine (U) samples were simultaneously collected at day (D) 7, and D 14 of GEN administration. Renal specimens from all donkeys were collected at D 14 and processed for routine histopathological examination. AKI was confirmed by sonography, laboratory measurements, histopathology and immunohistochemistry.

Keywords: Acute kidney injury; Equines; Inflammatory response; Immunohistochemistry

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