Journal of Liver: Disease & TransplantationISSN: 2325-9612

Reach Us +1 850 900 2634
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, J Liver Dis Transplant Vol: 1 Issue: 1

Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized 13C Magnetic Resonance Spectroscopy

Moses M. Darpolor1*, David E. Kaplan2, Peter L. Pedersen3 and Jerry D. Glickson1
1Departments of Radiology, University of Pennsylvania, Philadelphia, PA, USA
2Departments of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA
3Departments of Biological Chemistry and Oncology, Sidney Kimmel Cancer Research Center, and Center for Obesity Research & Metabolism, John Hopkins University, School of Medicine, Baltimore, MD, USA
Corresponding author : Moses M. Darpolor, PhD
University of Pennsylvania, Department of Radiology, B-6 Blockley Hall - 6021, 423 Guardian Drive, Philadelphia, PA 19104-6100, USA
E-mail: [email protected]
Received: July 13, 2012 Accepted: August 28, 2012 Published: August 31, 2012
Citation: Darpolor MM, Kaplan DE, Pedersen PL, Glickson JD (2012) Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized 13C Magnetic Resonance Spectroscopy. J Liver: Dis Transplant 1:1. doi:10.4172/2325-9612.1000101

Abstract

Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized 13C Magnetic Resonance
Spectroscopy

A characteristic feature of cancer cells is the alteration of their central carbon metabolism. It is generally acknowledged that for energy production cancer cells enhance their utilization of glycolysis and diminish that of oxidative phosphorylation irrespective of oxygen supply [1]. However, although mechanistic explanations for this enhanced glycolytic phenotype are controversial, it is likely due to the need for a versatile method for ATP production to serve as a direct form of energy, or as energy to drive both biosynthesis of vital intermediates for cell growth and provide anaplerotic flux for the tricarboxylic acid (TCA) cycle.

Keywords: Hepatocellular Carcinoma, �Warburg effect�, Hyperpolarized 13C MRS, [1-13C] pyruvate, Alanine Transaminase, Branched-Chain Aminotransferases

Track Your Manuscript

Share This Page