Journal of Regenerative Medicine ISSN: 2325-9620

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Research Article, J Regen Med Vol: 1 Issue: 1

Human Stem Cell Derivatives Retain More Open Epigenomic Landscape When Derived from Pluripotent Cells than from Tissues

Xuejun H. Parsons1,2*
1San Diego Regenerative Medicine Institute, San Diego, USA
2Xcelthera, San Diego, USA
Corresponding author : Xuejun H. Parsons
San Diego Regenerative Medicine Institute, San Diego, CA 92109, USA
Tel: 858-274-1621
E-mail: [email protected]
Received: October 31, 2012 Accepted: January 22, 2013 Published: January 25, 2013
Citation: Parsons XH (2012) Human Stem Cell Derivatives Retain More Open Epigenomic Landscape When Derived from Pluripotent Cells than from Tissues. J Regen Med 1:2. doi:10.4172/2325-9620.1000103

Abstract

Human Stem Cell Derivatives Retain More Open Epigenomic Landscape When Derived from Pluripotent Cells than from Tissues

The ability of a stem cell both to self-renew and differentiate into desired phenotypes makes it a potentially inexhaustible cell source for tissue and functional restoration. Discerning the complex identities of human stem cell derivatives from various developmental stages and sources is essential for selection of an optimally lineage-committed human stem cell with sufficient plasticity along the fate restriction continuum to address a particular disease.

Keywords: Human embryonic stem cells; Human pluripotent stem cells; Human neural stem cells; Human neuronal progenitors; Neurons; Human stem cell derivative; Epigenome; Acetylation; Methylation; ChIP-on-Chip; Chromatin; Oct-4; Differentiation; Lineage-specific;

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