Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Research Article, J Liver Dis Transplant Vol: 1 Issue: 2

Isolation and Characterization of Mesenchymal Stem Cells from Human Fetal Liver; Potential Candidates for Replacement Therapy in Liver Disease

Mohammed Saliem1*, Bo-Göran Ericzon2, Ewa Ellis2, Outi Hovatta1 and Cecilia Götherström1,3
1Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden
2Division of Transplantation Surgery, Karolinska Institutet, Stockholm, Sweden
3Center for Hematology and Regenerative Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Corresponding author : Mohammed Saliem MD
Karolinska Institutet, Department for Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology K57, 141 86 Stockholm, Sweden
Tel: +46 852488195; Fax: +46 87743191
E-mail: [email protected]
Received: August 01, 2012 Accepted: September 12, 2012 Published: September 15, 2012
Citation: Saliem M, Ericzon BG, Ellis E, Hovatta1 O, Götherström C (2012) Isolation and Characterization of Mesenchymal Stem Cells from Human Fetal Liver; Potential Candidates for Replacement Therapy in Liver Disease. J Liver: Dis Transplant 1:2. doi:10.4172/2325-9612.1000102

Abstract

Isolation and Characterization of Mesenchymal Stem Cells from Human Fetal Liver; Potential Candidates for Replacement Therapy in Liver Disease

Liver cell transplantation (LCT) is emerging as an alternative to organ transplantation in the treatment of liver disease since tissue unavailability and immunological incompatibilities are still major obstacles. Primary human hepatocytes are the first choice for LCT. However the unavailability of liver donors, the need for high numbers of hepatocytes for transplantation, immunological rejection, and low activity and inability to expand hepatocytes in vitro are limiting factors.

Keywords: Mesenchymal Stem Cells; Cell therapy; Liver disease; Hepatocytes; Co-transplantation

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