International Journal of Ophthalmic PathologyISSN: 2324-8599

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Case Report, Int J Ophthalmic Pathol Vol: 2 Issue: 2

Lymphomatous Optic Nerve Infiltration in Paediatric Cases

RN Hussain1*, C Chambers1 and G Woodruff1,2
1Leicester Royal Infirmary, UK
2University of Leicester, UK
Corresponding author: Hussain RN
Department of Ophthalmology, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK
Tel: 07903271112
Received: February 19, 2013 Accepted: March 19, 2013 Published: March 25, 2013
Citation: Hussain RN, Chambers C, Woodruff G (2013) Lymphomatous Optic Nerve Infiltration in Paediatric Cases. Int J Ophthalmic Pathol 2:2. doi:10.4172/2324-8599.1000112


We describe 2 children with stage IV anaplastic lymphoma with optic neuropathy due to optic nerve infiltration. Both children had an established diagnosis of anaplastic lymphoma prior to their ocular symptoms. Common symptoms included visual blurring and ocular pain, and examination revealed optic nerve head infiltration. Although one patient responded initially to systemic chemotherapy agents, both had residual severe visual impairment secondary to their optic nerve lesion and to the toxic effects of treatment for their central nervous system disease.

Anaplastic lymphoma is a rare cause of optic neuropathy. This is the first report of children with such a diagnosis with visual follow up; the visual prognosis seems to be poor and very resistant to treatment.

Keywords: Lymphoma; Optic nerve infiltration

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