Cell Biology: Research & TherapyISSN: 2324-9293

Special Issue Article, Cell Biol Res Ther S Vol: 0 Issue: 0

Mesenchymal Stem Cells: A New Old Tool to Improve Hematopoietic Stem Cell Transplant Outcome

Nassar A1,2*, Al Bessa M1,3, Abdel Latef N1,4 and El Sayed N1,3
1King Abdullah medical city, Mekka, Saudi Arabia
2National research center, Cairo, Egypt
3University of Alexandria, Alexandria, Egypt
4National cancer institute, Cairo, Egypt
Corresponding author : Amr Nassar, MD
King Abdullah Medical City, Al Mashaeer District, Mekka 57657, Saudi Arabia
Tel: 00966599375199/ 0096625549999; Fax:0096625532239-80149
E-mail: [email protected]
Received: July 01, 2013 Accepted: November 23, 2013 Published: November 27, 2013
Citation: Nassar A, Bessa MA, Latef NA, El Sayed N (2014) Mesenchymal Stem Cells: A New Old Tool to Improve Hematopoietic Stem Cell Transplant Outcome. Cell Biol: Res Ther S1:005 doi:10.4172/2324-9293.S1-005

Abstract

Mesenchymal Stem Cells: A New Old Tool to Improve Hematopoietic Stem Cell Transplant Outcome

Mesenchymal stem cells (MSCs) are a subpopulation of multipotent stem cells that exhibit a capacity to support hematopoiesis, play an immunomodulatory function and differentiate into different mesodermal tissues helping tissue repair. MSCs can be isolated and ex-vivo expanded from different tissues. Co-infusion of MSCs with hematopoietic stem cells (HSC) might have a positive effect on engraftment and graft versus host disease (GVHD) prophylaxis and management. However, the technique used for isolation and exvivo expansion needs to be both optimized as well as standardized to ensure the best outcome. In this review we will try to revise the clinical experience with collecting, expanding and utilizing MSCs in the setup of hematopoietic stem cell transplant (HSCT).

Keywords: Hematopoietic stem cell transplantation; Mesenchymal stem cell; Graft versus host disease; Engraftment

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