Cell Biology: Research & TherapyISSN: 2324-9293

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Review Article, Cell Biol Res Ther Vol: 4 Issue: 2

Metabolic Actions of Melatonin on Obesity and Diabetes: A Light in the Darkness

Flavio Fontes Pirozzi1*, Claudia Regina Bonini-Domingos2 and Milton Artur Ruiz1
1Portuguese Beneficent Hospital of São José do Rio Preto-SP, Brazil2Biology Department, IBILCE/UNESP of São José do Rio Preto-SP, Brazil
2Biology Department, IBILCE/UNESP of São José do Rio Preto-SP, Brazil
Corresponding author : Dr. Flávio Fontes Pirozzi
Division of Endocrinology of Medical School (Unilago) / Sao Jose do Rio Preto, SP, Brazil
Tel: +55(17) 99713-6049
E-mail: [email protected]
Received: September 16, 2015 Accepted: September 28, 2015 Published: September 30, 2015
Citation: Pirozzi FF, Bonini-Domingos CR, Ruiz MA (2015) Metabolic Actions of Melatonin on Obesity and Diabetes: A Light in the Darkness. Cell Biol: Res Ther 4:2. doi:10.4172/2324-9293.1000119

Abstract

Besides the known effects on sleep disorders, studies show that melatonin, a hormone produced mainly by the pineal gland, plays a key role in energy expenditure, food intake, glucose metabolism in adipocytes and regulating the secretion of various cytokines involved in weight control and appetite, such as leptin. In vitro and in vivo, both in animals and in humans, they demonstrate the potential benefits of melatonin supplementation on various diseases, including the metabolic disorders. This work aims to review the physiology of this hormone, its association with diseases such as obesity and diabetes, the benefits of supplementation of this hormone and the importance of research in the area for scientific evidence about the substance of this type. On the other hand, some countries, like Brazil, has regulated the marketing of this product which reduces the clinical research and the benefits that melatonin could bring to several patients.

Keywords: Melatonin; Obesity; Diabetes

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