Cell Biology: Research & TherapyISSN: 2324-9293

Research Article, Cell Biol Res Ther Vol: 4 Issue: 1

Modulation of Neurobehavioral and Biochemical Alterations Induced by Aluminum Chloride with Cannabis sativa Extract

Omar ME Abdel-Salam1*, Marawa El-Sayed El-Shamarka1 and Enayat A Omara2
1Department of Toxicology and Narcotics and Pathology, National Research Centre, Cairo, Egypt
2Department of Pathology, National Research Centre, Cairo, Egypt
Corresponding author : Omar M.E. Abdel Salam
Department of Toxicology and Narcotics, National Research Centre, Tahrir St., Dokki, Cairo, Egypt
Tel : +2-0 2-33335996
E-mail: [email protected]
Received: November 22, 2014 Accepted: April 16, 2015 Published: April 23, 2015
Citation: Abdel-Salam OM, El-Shamarka MES, Omara EA (2015) Modulation of Neurobehavioral and Biochemical Alterations Induced by Aluminum Chloride with Cannabis sativa Extract. Cell Biol: Res Ther 4:1. doi:10.4172/2324-9293.1000114

Abstract

Cannabis sativa preparations in the form of marijuana (the dried flowering tops and leaves) and hashish (the dried resin and compressed flowers) from the female plant Cannabis sativa is the most widely used illicit drugs worldwide. In humans, cannabis is associated with a spectrum of central nervous system effects. These include euphoria, relaxation and perceptual alterations, which are mediated by Δ9-tetrahydrocannabinol (Δ9-THC) the primary psychoactive constituent of cannabis. Other cannabinoids include cannabinol, cannabidiol, cannabigerol, cannabichromene, and cannabidivarin. Cannabinoid CB1 receptors have been cloned and identified in high concentration in several brain regions eg., hippocampus, basal ganglia, cerebellum and cerebral cortex.

Keywords: Cannabis sativa; Aluminum chloride; Brainoxidative stress; Behavioral changes

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