Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Research Article, J Liver Dis Transplant Vol: 3 Issue: 1

A New Pig Model of Auxiliary Partial Liver Transplantation Based on Anastomosis with Intrahepatic Inferior Vena Cava of Recipient

Bin Chen1, Xiaopeng Chen1*, Yongquan Chen2, Xiaojing Yang1, Linming Lu3, Xiangming Zhu4 and Fangman Chen4
1Department of General Surgery, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, 241001, China
2Anesthesia Department, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, 241001, China
3Pathology Department, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, 241001, China
4Medical Image Center, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, 241001, China
Corresponding author : Dr. Xiaopeng Chen
Department of Hepatobiliary Surgery, Yijishan Hospital, Wannan Medical College, No 2. , Zheshan West Road, Wuhu, Anhui Province, 241001, China
Tel: +86-553-5739626
E-mail: [email protected]
Received: January 18, 2014 Accepted: June 16, 2014 Published: June 20, 2014
Citation: Chen B, Chen X, Chen Y, Yang X, Lu L (2014) A New Pig Model of Auxiliary Partial Liver Transplantation Based on Anastomosis with Intrahepatic Inferior Vena Cava of Recipient. J Liver: Dis Transplant 3:1. doi:10.4172/2325-9612.1000118

Abstract

A New Pig Model of Auxiliary Partial Liver Transplantation Based on Anastomosis with
Intrahepatic Inferior Vena Cava of Recipient

Auxiliary partial orthotopic liver transplantation (APOLT) is a feasible approach to treat patients with fulminant hepatic failure and metabolic liver diseases. It is still necessary to establish a simple and reliable APOLT model using large animals for deep research.Ten healthy male or female domestic pigs, weighing 20- 35 kg, were randomly selected to be either donor group (n=8) or recipient group (n=8). The right liver of donor was used as a graft. After the left lobe of recipient was resected, the anterior wall of the distal intrahepatic inferior vena cava was properly dissected. Endto- side anastomosis was performed between graft suprahepatic inferior vena cava and host distal intrahepatic inferior vena cava. End-to-side anastomosis was performed between the donor and recipient portal veins. After the spleen of recipient was resected, end-to-end anastomosis was made between graft hepatic artery and host splenic artery, and a cannula was inserted into host splenicvein for postoperative portal phlebography. The common bile duct of donor was intubated for external drainage.

Keywords: Auxiliary partial orthotopic liver transplantation; Intrahepatic inferior vena cava; Pig model

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