Journal of Molecular Medicine & Therapeutics#

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Short Communication, Mol Med Ther Vol: 1 Issue: 2

Novel Combinatorial Therapeutic Targeting of PAI-1(SERPINE1) Gene Expression in Alzheimer’s Disease

Stacie M. Kutz1, Craig E. Higgins2 and Paul J. Higgins2*
1Department of Biology, Sage College of Albany, Albany, NY 12208, USA
2Center for Cell Biology & Cancer Research, Albany Medical College 47 New Scotland Avenue, Albany, NY 12208, USA
Corresponding author : Dr. Paul J. Higgins
Center for Cell Biology & Cancer Research, Albany Medical College 47 New Scotland Avenue, Albany, NY 12208, USA
E-mail: [email protected]
Received: November 06, 2012 Accepted: December 10, 2012 Published: December 13, 2012
Citation: Kutz SM, Higgins CE, Higgins PJ (2012) Novel Combinatorial Therapeutic Targeting of PAI-1 (SERPINE1) Gene Expression in Alzheimer’s Disease. Mol Med Ther 1:2. doi:10.4172/2324-8769.1000106

Abstract

Novel Combinatorial Therapeutic Targeting of PAI-1(SERPINE1) Gene Expression in Alzheimer’s Disease

Accumulation of neurotoxic amyloid peptides (Aβ) in the brain, generated by β-site proteolytic processing of the amyloid precursor protein (APP), is the hallmark pathophysiologic feature of Alzheimer’s disease. The plasmin-activating cascade, in which urokinase (uPA) and tissue-type (tPA) plasminogen activators convert plasminogen to the broad-spectrum protease plasmin, appears to serve a protective, Aβ-clearing, role in the central nervous system.

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