Journal of Regenerative MedicineISSN: 2325-9620

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Research Article, J Regen Med Vol: 3 Issue: 1

Novel Nanocrystalline Hydroxyapatite for Bone Regeneration

Orlando Martins1, Sérgio Matos1, Maria Helena Figueiredo1, Carlos Viegas2,3, Isabel Dias2,3,4, Teresa Vieira5, Pedro Nuno Lopes6, Isabel Poiares Baptista1 and Fernando Guerra1
1Dentistry Department, Faculty of Medicine - University of Coimbra, Coimbra, Portugal
2Agricultural and Veterinary Sciences School, Department of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, Vila Real, Portugal
3B’s Research Group: Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Portugal
4Life and Health Sciences Research Institute – ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
5Mechanical Engineering Department, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
6Medical Services, University of Coimbra, Coimbra, Portugal
Corresponding author : Orlando Martins
Dentistry Department, Faculty of Medicine, University of Coimbra Av. Bissaya Barreto – Blocos de Celas, 3000-075 Coimbra, Portugal
Tel: +351 239484183; Mobile: +351917298190; Fax: +351 239402910
E-mail :
Received: February 03, 2014 Accepted: August 11, 2014 Published: August 17, 2014
Citation: Martins O, Matos S, Figueiredo MH, Viegas C, Dias I, et al. (2014) Novel Nanocrystalline Hydroxyapatite for Bone Regeneration. J Regen Med 3:1. doi:10.4172/2325-9620.1000114


Novel Nanocrystalline Hydroxyapatite for Bone Regeneration

Maxillofacial bone defects resulting from disease or trauma are one main problem for modern dentistry. Regenerative treatments aim to provide the lost initial conditions improving the patient’s life quality. Bone graft substitutes have been regarded as suitable alternatives to obtain regenerative outcomes. Among these, synthetic hydroxyapatites are successfully evaluated bone substitutes, both in pre-clinical as well as clinical studies. The aim of this study is to evaluate the bone regenerative potential of a nanocrystalline hydroxyapatite (nHA), in a delayed healing cranial rabbit model.

Keywords: Animal model; Bone graft; Bone regeneration; Hydroxyapatite

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