Journal of Clinical & Experimental OncologyISSN: 2324-9110

Review Article, J Clin Exp Oncol S Vol: 0 Issue: 0

Oncology and Biophysics: A Need for Integration

Sarah S Knox1* and Richard HW Funk2
1Department of Epidemiology, School of Public Health,West Virginia University, Morgantown, WV 26506, USA
2Institute of Anatomy and Center for Regenerative Therapies, Fiedlerstr 42 and Tatzberg, 01307 Dresden, USA
Corresponding author : Sarah Knox
Department of Epidemiology, School of Public Health, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA
Tel: 304-293-1058
E-mail: [email protected]
Received: August 12, 2013 Accepted: January 20, 2014 Published: January 28, 2014
Citation: Knox SS, Richard HWF (2014) Oncology and Biophysics: A Need for Integration. J Clin Exp Oncol S1. doi:10.4172/2324-9110.S1-001

Abstract

Oncology and Biophysics: A Need for Integration

The mainstream view of cancer as a mutated cell that has become dysfunctional and multiplies out of control (the somatic mutation model) is much less consistent with extant data than the context dependent model. The latter focuses on interactions between the cell and its surrounding environment as the initiator and driver of malignancy. The genome wide epigenetic changes that precede cancer and confer risk for cancer, strongly suggest that multiple systems are affected by gene expression changes before tumors even manifest. This provides a partial explanation for cancer’s ability to adapt to targeted therapies as well as an explanation for the failure of multiple DNA repair mechanisms and other defenses(e.g. apoptosis, immune defenses) to eliminate mutated cells.

Keywords: Oncology; Biophysical signaling; Epigenetics; Epithelial mesenchymal transition; Systems biology

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