Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Research Article, J Clin Exp Oncol Vol: 2 Issue: 4

p53 Gene Inactivation Modulate Methylenetetrahydrofolate C677T Gene Polymorphism Associated Risk Factor for the Development of Cervical Carcinoma -A Tissue specific Genetic Heterogeneity

GK Singh1, Ajit K Saxena1*, Anjula2, Garima2, S Pandey2 and LK Pandey2
1Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Patna, India
2Department of Obstetrics and Gynecology, Institute of Medical Sciences, B.H.U., Varanasi, India
Corresponding author : Dr. Ajit K Saxena
Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Patna-801505, (Bihar) India
Tel: 0917781012677;Fax: (623) 321-1528
E-mail: [email protected]
Received: September 19, 2013 Accepted: November 12, 2013 Published: November 18, 2013
Citation: Singh GK, Saxena AK, Anjula, Garima, Pandey S, et al. (2013) p53 Gene Inactivation Modulate Methylenetetrahydrofolate C677T Gene Polymorphism Associated Risk Factor for the Development of Cervical Carcinoma -A Tissue Specific Genetic Heterogeneity. J Clin Exp Oncol 2:3. doi:10.4172/2324-9110.1000114

Abstract

p53 Gene Inactivation Modulate Methylenetetrahydrofolate C677T Gene Polymorphism Associated Risk Factor for the Development of Cervical Carcinoma -A Tissue specific Genetic Heterogeneity

Inconsistently, epidemiological studies reveals that folate regulate a significant role in DNA synthesis and etiopathology of cervical cancer in women. Folate, an essential dietary component require for DNA methylation during cell proliferation. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methylenetetrahydrofolate involved in the methylation of homocysteine to methionine. A common substitution of this enzyme gene variant 677 C → T (Ala → Val) shown to reduced activity results mild hyperhomocysteinemia. We have collected the blood sample from those patients having lack of infection form human papilloma virus (HPV).

Keywords: MTHFR; Gene Polymorphism; Cervix Cancer; Risk factor; HeLa cell line

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