Journal of Molecular Medicine & Therapeutics#

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Review Article, Mol Med Ther Vol: 1 Issue: 2

Parkinsonís Disease and Type-2 Diabetes: Methylglyoxal may be a Common Causal Agent; Carnosine could be Protective

Alan R. Hipkiss*
Aston Research Centre for Healthy Ageing (ARCHA), School of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK
Corresponding author : Dr. Alan R. Hipkiss
Aston Research Centre for Healthy Ageing (ARCHA), School of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK
E-mail: [email protected]
Received: September 10, 2012 Accepted: November 15, 2012 Published: December 08, 2012
Citation: Hipkiss AR (2012) Parkinson’s Disease and Type-2 Diabetes: Methylglyoxal may be a Common Causal Agent; Carnosine could be Protective. Mol Med Ther 1:2. doi:10.4172/2324-8769.1000104

Abstract

Parkinson’s Disease and Type-2 Diabetes: Methylglyoxal may be a Common Causal Agent; Carnosine could be Protective

The likelihood that the type-2 diabetes influences the incidence of Parkinson’s disease (PD), via increased generation of methylglyoxal (MG), is examined in the light of recent evidence. Animal experiments (mice and dogs) have shown that high glycemic index diets increase tissue MG levels, while low glycemic index diets in humans are associated with a decreased incidence of PD. Proteomic studies have revealed an increased activity of the carnosinase, CNDP2, in the substantia nigra of PD patients.

Keywords: Parkinsonís disease; Methylglyoxal; Glycolysis; Triose phosphates; Dopamine; Glycation; Neuropathy; Hyperalgesia; Carnosinase

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