Journal of Regenerative Medicine ISSN: 2325-9620

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Research Article, J Regen Med Vol: 5 Issue: 2

A combined use of Chondrocytes Micro Grafts (CMG) Mixed with Platelet Rich Plasma (PRP) in Patients Affected by Pinch Nose Deformity

Gentile P1*, Scioli MG2, Bielli A2, Orlandi A3 and Cervelli V4
1Plastic and Reconstructive Surgery Department, University of Rome “Tor Vergata”, Rome, Italy
2Institute of Anatomic Pathology, University of Rome Tor Vergata, Italy
3Chief of Anatomic Pathology University of Rome Tor Vergata, Italy
4Chief of Plastic and Reconstructive Surgery Department, University of Rome“Tor Vergata”, Italy
Corresponding author : Pietro Gentile, MD, PhD
Via Courmayeur, No. 102, 00135 Rome, Italy
Tel: +39-3388515479
E-mail: [email protected]
Received: July 06, 2016 Accepted: July 27, 2016 Published: August 01, 2016
Citation: Gentile P, Scioli MG, Bielli A, Orlandi A, Cervelli V (2016) A combined use of Chondrocytes Micro Grafts (CMG) Mixed with Platelet Rich Plasma (PRP) in Patients Affected by Pinch Nose Deformity. J Regen Med 5:2. doi:10.4172/2325-9620.1000129

Abstract

Background: The combined use of autologous chondrocytes micro-grafts (CMG) mixed with Platelet Rich Plasma (PRP) is an alternative that opens a new era in this field.

Materials and Methods: At the Department of Plastic and Reconstructive Surgery, University of Rome “Tor Vergata”, Italy, 15 patients, affected by pinch nose deformity underwent nasal alar reconstruction with chondrocytes micro-grafts gentle poured onto PRP in solid form. A CT scan control was performed after 12 months. Pearson’s Chi-square test was used to investigate difference in cartilage density (CD) between native and newly formed cartilage.

Results: The constructs of CMG-PRP subcutaneously injected resulted in cartilage tissue with adequate central nutritional perfusion. Postoperative follow-up evaluation has shown optimal aesthetic results and improvement of nasal obstruction. These composite grafts provide functional support to the alar cartilages, usually collapsed in pinch nose deformity because of excessive resection during previous surgery.

Conclusion: This report demonstrated that chondrocytes micrografts derived from nasal septum poured onto PRP in solid form are a useful method for cartilage regeneration in patients affected by external nasal valve collapse.

Keywords: Chondrocytes auto-graft; Cartilage regeneration; Cartilage tissue engineering

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