Opinion Article, J Spine Neurosurg Vol: 11 Issue: 3
Acute Radicular Symptoms Due to Hemorrhage into Synovial Cysts
Received date: 01 March, 2022, Manuscript No. JSNS-22-57859;
Editor assigned date: 03 March, 2022, PreQC No. JSNS-22-57859 (PQ);
Reviewed date: 17 March, 2022, QC No JSNS-22-57859;
Revised date: 21 March, 2022, Manuscript No. JSNS-22-57859 (R);
Published date: 31 March, 2022, DOI: 10.4172/2325-9701.1000123
Citation: Endo M (2022) Acute Radicular Symptoms Due to Hemorrhage into Synovial Cysts. J Spine Neurosurg 11:3.
Keywords: Acute Radicular, Hemorrhage, Synovial, Cysts, Spine
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Nucleic Acid Nanotechnology
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HP1 proteins are best known as markers of heterochromatin and gene silencing. Yet, they are also RNA-binding proteins and the HP1γ/CBX3 family member is present on transcribed genes together with RNA polymerase II, where it regulates co-transcriptional processes such as alternative splicing. To gain insight in the role of the RNA-binding activity of HP1γ in transcriptionally active chromatin, we have captured and RNAs associated with this protein. We find that HP1γ is specifically targeted to RNA motifs and coincidentally transposable elements of the SINE family. As these elements are abundant in introns, while essentially absent from exons, the HP1γ RNA association tethers pre-mRNA to chromatinvia the regions and limits the usage of cryptic splice sites. Thus, our data unveil novel determinants in the relationship between chromatin and co-transcriptional splicing.