Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Case Report, J Clin Exp Oncol Vol: 6 Issue: 1

Can Medulloblastoma be Presented with Primary Diffuse Leptomeningeal Gliomatosis? Case Report and Literature Review

Hassoun HK1, Sattar Al-Essawi1, Taki Al Tiraihi2, Aseel A Abdul Wahab3, Amar Saeed Rasheed1, Imad Al-Sabri4 and Zuhair Allebban4*
1Middle Euphrates Neuroscience Center, Kufa University-College of Medicine, Najaf, Iraq
2Department of pathology, Terbaite Modares University, Tehran, Iran
3Department of pathology, Kufa University-College of Medicine, Najaf, Iraq
4Middle Euphrates Cancer Research Unit, Kufa University-College of Medicine, Najaf, Iraq
Corresponding author : Zuhair Allebban, BVMS, MS, PhD, MB(ASCP), M(ASCP)
Director, Middle Euphrates Cancer Research Unit, Professor of Pathology, Kufa University-College of Medicine, P.O. Box 21, Najaf, Iraq
Tel:
+964 7804272223
E-mail:
[email protected]
Received: January 06, 2017 Accepted: January 23, 2017 Published: January 28, 2017
Citation: Hassoun HK, Al-Essawi S, Tiraihi TA, Wahab AAA, Rasheed AS, et al. (2017) Can Medulloblastoma be Presented with Primary Diffuse Leptomeningeal Gliomatosis? Case Report and Literature Review. J Clin Exp Oncol 6:1. doi: 10.4172/2324-9110.1000175

Abstract

Primary diffuse leptomeningeal Gliomatosis (PDLG) is a rare neoplastic condition characterized by primary infiltration of leptomeninges by malignant glial cells which is extremely rare to be as a result of medulloblastoma. To the best of our knowledge, there are only 5 reported localized forms of PDLG cases due to medulloblastoma affecting mainly posterior fossa and/or part of cerebrum. In this article, we are reporting for the first time a case of PDLG with extensive diffuse involvement of leptomeninges due to medulloblastoma extending from the cerebrum to sacral area in 4-year old child presented with acute headache, abducent nerve palsy and papilledema with dramatic response to chemotherapy.

Keywords: Primary diffuse leptomeningeal gliomatosis; Medulloblastoma;Leptomeningeal metastasis

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