Cell Biology: Research & TherapyISSN: 2324-9293

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Short Communication, Cell Biol Res Ther Vol: 2 Issue: 2

Chemotherapy Increases Aggressiveness of Prostate Cancer via Epithelial Mesenchymal Transition

John J Kim1,2,3, James E Verdone2,3 and Steven M Mooney1,2,3*
1University of California, Berkeley and University of California, San Francisco Graduate Program in Bioengineering, USA
2The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
3Department of Biomedical Engineering, Whiting School of Engineering, The Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
Corresponding author : Steven M. Mooney, Ph.D
James Buchanan Brady Urological Institute, Department of Urology and Oncology, Johns Hopkins University School of Medicine, 600 N. Wolfe St. 129B Marburg, Baltimore, MD 21287, USA
Tel: 410-614-0120
Fax: 410-502-9336
E-mail: [email protected]
Received: June 20, 2013 Accepted: August 13, 2013 Published: August 16, 2013
Citation: Kim JJ, Verdone JE, Mooney SM (2013) Chemotherapy Increases Aggressiveness of Prostate Cancer via Epithelial Mesenchymal Transition. Cell Biol: Res Ther 2:2. doi:10.4172/2324-9293.1000105

Abstract

Chemotherapy Increases Aggressiveness of Prostate Cancer via Epithelial Mesenchymal Transition

Although chemotherapy has been used as a major therapeutic weapon against advanced prostate cancer, overcoming drug resistance is still a major challenge. Cancer has been known to diminish therapeutic effect by several molecular mechanisms– increasing efflux by recruiting cell membrane pumps and limiting drug diffusion by constructing leaky vasculature. Moreover, recent studies suggest that long-term treatment with chemotherapy may have detrimental effects for patients presenting with solid tumors. Specifically, prostate cancer epithelial cells develop resistance to chemotherapy and may convert into mesenchymal cells. This switching process, known as Epithelial to Mesenchymal Transition (EMT), is a critical precursor in prostate cancer invasion and metastasis.

Keywords: Epithelial to mesenchymal transition; Cancer metastasis; Chemotherapy; Drug resistance

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