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Journal of Veterinary Science & Medical Diagnosis ISSN: 2325-9590

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Research Article, J Vet Sci Med Diagn Vol: 5 Issue: 6

Chicken Amyloid Arthropathy Caused by Mycoplasma Synoviae Infection in Japan

Naoki Kobayashi1, Tomoaki Murakami2*, Hiroki Sakai1, Yui Yamaguchi3, Hideto Fukushi3 and Tokuma Yanai1
1Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan
2Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan
3Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan
Corresponding author : Tomoaki Murakami
Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho,Fuchu-shi, Tokyo 183-8509, Japan
E-mail: [email protected]
Received: August 29, 2016 Accepted: September 27, 2016 Published: November 21, 2014
Citation: Kobayashi N, Murakami T, Sakai H, Yamaguchi Y, Fukushi H, et al. (2016) Chicken Amyloid Arthropathy Caused by Mycoplasma Synoviae Infection in Japan. J Vet Sci Med Diagn 5:6. doi: 10.4172/2325-9590.1000211

Abstract

Chicken Amyloid Arthropathy Caused by Mycoplasma Synoviae Infection in Japan

Chicken amyloid A (AA) amyloidosis is a fatal disease in adult birds with chronic inflammatory disorders. In white chickens, AA amyloidoses are observed as vaccine-associated amyloidosis. Meanwhile, in colored chickens, AA amyloidoses are generally known as amyloid arthropathy. Chicken amyloid arthropathy is typically caused by infection with Enterococcus faecalis. Mycoplasma synoviae was rarely reported as a causative agent for amyloid arthropathy. In this study, 36 brown layers that showed severe leg joint swelling and remarkable growth delay were examined by using histopathology, immunohistochemistry, ultrastructural morphology, bacteriology, and molecular biology. Histologically, severe amyloid deposits were observed in the leg joint synovium, and mild to moderate amyloid deposits were observed in the liver and spleen. In the synovium, amyloid deposits were observed at the same site as the orange area observed on gross examination. On ultramicroscopy, amyloid fibrils density in the synovium was observed to be higher than that in the liver. Polymerase chain reaction test revealed an M. synoviae infection in lesions, but not E. faecalis. This is the first report of chicken amyloid arthropathy by single infection of M. synoviae in Asia.

Keywords: Amyloid arthropathy; Chicken; Mycoplasma synoviae

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