International Journal of Ophthalmic PathologyISSN: 2324-8599

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Research Article, Int J Ophthalmic Pathol Vol: 5 Issue: 4

Cyclooxygenase Expression in Conjunctival Squamous Cell Carcinoma

Capiz Correa D1*, Robles-Contreras A2, Tejeda-Rojas G1 and Sanchez Moreno F3
1Medical Staff Member of the Orbit and Occuloplastics department at Foundation Hospital Nuestra Señora de la Luz IAP, Mexico City, Mexico
2Chief Researcher at Health Sciences Research Department at Foundation Hospital Nuestra Señora de la Luz IAP, Mexico City, Mexico
3Second year resident of Ophthalmology at Foundation Hospital Nuestra Señora de la Luz IAP, Mexico City, Mexico
Corresponding author : Capiz Correa D
Medical Staff Member of the Orbit and Occuloplastics department at Foundation Hospital Nuestra Señora de la Luz IAP, Mexico City, Mexico
Tel: +55 51 28 11 40
E-mail: [email protected]
Received: September 29, 2016 Accepted: November 11, 2016 Published: November 17, 2016
Citation: Capiz Correa D, Robles-Contreras A, Tejeda-Rojas G, Sanchez Moreno F (2016) Cyclooxygenase Expression in Conjunctival Squamous Cell Carcinoma. Int J Ophthalmic Pathol 5:4. doi: 10.4172/2324-8599.1000190

Abstract

Purpose: To determine cyclooxygenase 1 and cyclooxygenase 2 expression in conjunctival squamous cell carcinoma.

Methods: Prospective experimental case series of 24 tissue samples diagnosed with squamous cell carcinoma between 2010 and 2012 at Foundation Hospital Nuestra Señora de la Luz and determine cyclooxygenase 1 and 2 expression.

Results: 24 slides with diagnosis of conjunctival squamous cell carcinoma were processed; 50% from male patients and 50% from female patients. From the 24 samples; 23 rendered primary CSCC and 1 recurrent CSCC. In all of the samples, COX-2 and COX-1 were expressed, although these did not correlate to the level of invasion and grade of differentiation.

Conclusions: We found the expression of COX-1 to be a predominant marker in conjunctival tissue. COX-2 expression was found in higher levels at zones or borders of the tumor; as confirmed by an histopathological result of squamous cell carcinoma.

Keywords: Conjunctiva; Squamous surface neoplasia; Cyclooxygenase; Squamous cell carcinoma; Conjunctival dysplasia

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