Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Review Article,  J Liver Disease Transplant Vol: 7 Issue: 1

Dilemma of Hepatic Ischemia Reperfusion Injury after Liver Transplantation

Mohamed Ismail Seleem* and Ahmed Elewa

Department of Hepato-Pancreatico-Biliary surgery & Liver Transplantation, National Hepatology & Tropical Medicine Research Institute (NHTMRI), Egypt

*Corresponding Author : Mohamed Ismail Seleem, FRCS, MD
Head of Hepato-Pancreatico-Biliary Surgery Department, National Hepatology and Tropical Research Institute-Cairo-Egypt 11, Mo-Ezz Eldawlah off Makram Obied Street, Nasr City, Cairo-Egypt
Tel: +201113447442; +20222737089

Received: January 17, 2018 Accepted: February 06, 2018 Published: February 13, 2018

Citation: Seleem MI, Elewa A (2018) Dilemma of Hepatic Ischemia-Reperfusion Injury after Liver Transplantation. J Liver Disease Transplant 7:1. doi: 10.4172/2325-9612.1000159


Liver transplantation, whether from a deceased or living donor (LDLT), is still a definite line of treatment for decompensated cirrhosis, early stage of hepatocellular carcinoma, and acute liver failure. Organs from living donors offer many potential advantages over organs from deceased donors; the most important is the optimization of the timing of transplantation. Also preservation time is minimal, so there is significantly less ischemic damage. Time-zero biopsies sampled after graft revascularization predicts adverse clinical outcomes after liver transplantation. It is well known that severe Ischemia/reperfusion injury (IRI) signals the likely need for early retransplantation. This fact emphasizes the value of the time –zero biopsy sampled immediately after graft reperfusion. Hepatic Ischemia-Reperfusion Injury after Liver Transplantation is a common and major complication after liver surgery and transplantation. It impairs liver function, increases postoperative morbidity and mortality, interferes with recovery and thus has a major impact on clinical outcomes.

Keywords: Hepatic Ischemia-Reperfusion Injury; Liver Transplantation; Time zero biopsies

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