Cell Biology: Research & TherapyISSN: 2324-9293

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, Cell Biol Henderson Nv Vol: 6 Issue: 2

Immunohistochemical Markers of Angiogenesis and Apoptosis in Chorionic Villi during Early Pregnancy Miscarriage

Igor Zastavnyy1, Antonina Yashchenko1, Igor Shponka2 and Iryna Tkach3

1Danylo Halytsky Lviv National Medical University, Department of Histology, Cytology and Embryology, Lviv, Ukraine

2Dnipropetrovsk Medical Academy of Health Ministry of Ukraine, Department of Pathological Anatomy and Forensic Medicine, Dnipro, Ukraine

3Institute of Hereditary Pathology of National Academy of Medical Sciences of Ukraine, Lviv, Ukraine

*Corresponding Author : Igor Zastavnyy
Department of Histology, Cytology and Embryology, Danylo Halytsky Lviv National Medical University, Ukraine
Tel: +380322769373
E-mail: ihor.zastavnyy@gmail.coml

Received: December 12, 2017 Accepted: December 21, 2017 Published: December 28, 2017

Citation: Zastavnyy I, Yashchenko A, Shponka I, Tkach I (2017) Changes in the Expression of Immunohistochemical Markers of Angiogenesis and Apoptosis in Chorionic Villi during Early Pregnancy Miscarriage. Cell Biol (Henderson, NV) 6:2. doi: 10.4172/2324-9293.1000135


Objective: Aim of this study was to investigate changes in the expression of immunohistochemical markers of angiogenesis (VEGF) and apoptosis (Caspase 3) in chorionic villi of human embryos, obtained after sporadic, recurrent pregnancy miscarriage and compare them with such expression in normal pregnancy Chorionic villie.

Methods: Histological material included 63 recurrent, sporadic miscarriage and 32 artificial abortions chorionic villi samples. Immunohistochemical technique was applied to study expression levels of VEGF and Caspase 3.

Results: VEGF and Caspase 3 expression intensity and diversity in different Chorionic villie (CV) structural components was observed in different investigated groups.

 Conclusion: Our research has shown that an important role is played not only by a general decrease in VEGF expression but also a change in the allocation of this cytokine in the structural components of early pregnancy miscarriage CV. The processes of apoptosis were more active in the groups of early miscarriage; however, they did not block the synthesis of VEGF. These results may indicate the role of factors of angiogenesis and apoptosis in the development of early miscarriage of pregnancy.

Keywords: Immuno histochemical markers; Early pregnancy miscarriage; Idiopathic pregnancy

international publisher, scitechnol, subscription journals, subscription, international, publisher, science

Track Your Manuscript

Awards Nomination
open access