Journal of Clinical Immunology and Research

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Research Article, J Clin Immunol Res Vol: 3 Issue: 4

Immunophenotypic Characterization of ART- naive, HIV Infected Adults in Kombewa Sub-county, Kisumu: A Cross Sectional Study of Rural Population in Western Kenya



Reliable information on clinical immunophenotypic biomarkers is critical in the management of Hepatitis B and C infections especially in ART naive HIV positive adults. CD4 cell counts and the level of liver function bio-molecules can be monitored to assess the body status and treatment response to interventions. This was a cross sectional laboratory investigation study aimed at investigating the immunological phenotypes in HIV positive adults from Kisumu West Sub-county, so that overall patient care, participation of individuals in clinical trials and evaluation of adverse events can be improved. Median ALT values in Hepatitis C positive HIV positive ART Naive participants were higher than in the Hepatitis C negative participants (p=0.0494). The study underscores the need for monitoring liver enzymes levels in ART naive HIV positive patients as well, screening for viral hepatitis before initiation of Anti-Retro Viral therapy as these diseases pathologically alters the body’s immune biomarkers.

Keywords: Immunophenotypic; Hepatitis C; ART naïve; HIV positive; CD4 cellcounts


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