Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Review Article, J Clin Exp Oncol Vol: 6 Issue: 1

Immunosurveillance in Colorectal Carcinomas with Microsatellite Instability

Chiara Rodrigues1*, Daniel Romeira2, Marta Pinto1, Ana Massena1, Helena Miranda1 and Ana Martins Mourão1
1Medical Oncology Department, Ocidental Lisbon Hospital Centre, Portugal
2Medical Oncology Unity, Lisbon Lusíadas Hospital, Portugal
Corresponding author : Chiara Rodrigues
Medical Oncology Department, Ocidental Hospital Centre of Lisbon, Estrada do Forte do Alto do Duque, 1449-005 Lisbon, Portugal
Received: January 21, 2017 Accepted: February 02, 2017 Published: February 09, 2017
Citation: Rodrigues C, Romeira D, Pinto M, Massena A, Miranda H, et al. (2017) Immunosurveillance in Colorectal Carcinomas with Microsatellite Instability. J Clin Exp Oncol 6:1. doi: 10.4172/2324-9110.1000176


Tumour infiltrating lymphocytes have been associated to a better prognosis in colorectal cancers. Microsatellite unstable tumours present a greater infiltration by these immune cells when comparing to microsatellite stable tumours. It has been suggested that lymphocytic infiltration may be an indicator of a host immune response against tumour cells and therefore, contribute to a better prognosis. High microsatellite instability (MSI-H) tumours have been shown to bare a better prognosis and some authors believe that TILs infiltration take a part in this. Nonetheless, the significance of tumour infiltrating lymphocytes (TILs), their distribution and prognostic value are still unclear. The aim of this review is to summarize the current evidence on tumour infiltrating lymphocytes characteristics, distribution, activity and relation to prognosis in microsatellite unstable colorectal tumours.

Keywords: Tumor-infiltrating lymphocytes; Colorectal cancer; Microsatellite instability; Prognosis

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