Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Research Article, J Clin Exp Oncol Vol: 4 Issue: 4

Malignant Tumours of the Female Genital Tract: A 10-Year Histopathological Review at the Korle-Bu Teaching Hospital(2002-2011)

Der EM1,3*, Kwame-Aryee RA2, Tettey Y1, Seffah JD2, Wiredu EK1, Adu-Bonsaffoh K2, Gyasi RK1
1Department of Pathology, University of Ghana Medical School, KBTH, Accra-Ghana
2Department Obstetrics and Gynaecology , University of Ghana Medical School, KBTH, Accra-Ghana
3Department of Pathology, School of Medicine and Health Sciences, University for Development Studies, Tamale-Ghana
Corresponding author : Dr. Der Muonir Edmund
School of Medicine, University for Development Studies, Tamale, Ghana
Tel: 0208709807
E-mail: [email protected]
Received: August 03, 2015 Accepted: November 04, 2015 Published: November 11, 2015
Citation: Der EM, Kwame-Aryee RA, Tettey Y, Seffah JD, Wiredu EK, et al. (2015) Malignant Tumours of the Female Genital Tract: A 10-Year Histopathological Review at the Korle-Bu Teaching Hospital (2002-2011). J Clin Exp Oncol 4:4.. doi:10.4172/2324-9110.1000146

Abstract

Malignant Tumours of the Female Genital Tract: A 10-Year Histopathological Review at the Korle-Bu Teaching Hospital (2002-2011)

Abstract

Background: Morbidity data on female genital tract malignancies are limited in Ghana. The aim of this study was to establish the anatomical distribution and the histopathological features of female genital tract malignancies (FGTMs) in a tertiary hospital in Ghana.

Material and methods: A comprehensive review of the all histologically confirmed FGTMs from January 2002 to December 2011 was conducted to assess their clinicopathological features.

Results: There were 1,536 cases of FGTMs. The anatomic distributions were: uterine cervix 1086 (70.7%), corpus uteri 356 (23.2%), vagina 58 (3.8%) and vulva 36 (2.3%). The mean ages of women diagnosed with these cancers were: corpus uteri (59.5 years; SD = 14.2), uterine cervix (57.7 years; SD = 13.8), vulva (56.3 years; SD = 13.4) and vagina (52.5 years; SD = 18.1). The proportions of postmenopausal women were: corpus uteri (76.8%), uterine cervix (65%), vulva (55.6%) and vagina (50.0%). Women with corpus uteri and uterine cervix malignancies presented commonly with bleeding per vaginam while those with vulva and vagina malignancies presented mostly with ulcers and masses. The common histological subtypes were; cervix: Squamous cell carcinoma (SCC) (69.2%), adenocarcinoma (18.1%) and MMMT (3.8%) (2.3%); Corpus uteri: adenocarcinoma (61.8%), malignant mixed mullerian tumours (MMMT) (15.4%) and choriocarcinoma (8.4%); Vagina: SCC (62.1%), adenocarcinoma (22.4%) and MMMT (5.2%); Vulva were: SCC (69.4%), adenosquamous (8.25) and stroma (5.6%).

Conclusion: The study found that FGTMs were commoner in relatively older women (mean age 57.9 years), majority being postmenopausal (66.4%). The predominant type of FGTM was cancer of the uterine cervix with bleeding per vaginam as the common clinical presentation.

Keywords: Female Genital tract malignancies; Ghana; Postmenopausal; MMMT

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