Analgesia & Resuscitation : Current ResearchISSN: 2324-903X

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Opinion Article, Analg Resusc Curr Res Vol: 10 Issue: 6

Neuropathic pain: Classification, Etiology and Epidemiology

Mahmoud M. Alseoudy*

Department of Anesthesia and Surgical Intensive Care, Mansoura University, Mansoura, Egypt

*Corresponding Author:
Mahmoud M. Alseoudy
Department of Anesthesia and Surgical Intensive Care, Mansoura University, Mansoura, Egypt

Received Date: November 13, 2021; Accepted Date: November 29, 2021; Published Date: December 04, 2021

Citation: Alseoudy MM (2021) Neuropathic pain: Classification, Etiology and Epidemiology. Analg Resusc: Curr Res 10:6. 177.

Copyright: © All articles published in Analgesia & Resuscitation: Current Research are the property of SciTechnol, and is protected by copyright laws. Copyright © 2021, SciTechnol, All Rights Reserved.

Keywords: Neuropathic pain


Neuropathic pain may be classified according to the underpinning lesion or complaint or according to the clinical phenotype. While the clinical phenotype may be useful for future substantiated NP operation, the 11th edition of the International Bracket of Conditions (ICD-11) differentiates NP of supplemental and central origin, comprising nine typical conditions associated with patient or intermittent pain. There are also extension canons for pain inflexibility (combining intensity, torture, and disability), temporal characteristics and cerebral or social factors, as well as a link to the International Bracket of Performing (ICF). Generally, NP is considered to be habitual, as it either persists continuously or manifests with intermittent painful occurrences and is generally not limited by the natural mending process or treatment of the underpinning complaint. The IASP bracket of habitual NP for ICD-11 represents the first methodical bracket to date of common painful neurological diseases; member countries are anticipated to report health statistics to WHO according to ICD-11 from 2022 onward. Therefore, pDN is classified as habitual NP (top/ first-position opinion) of supplemental origin (habitual supplemental NP; alternate- position opinion), painful polyneuropathy (third- position opinion). From the clinical point of view, a physical examination is pivotal to (1) link the case’s pain to a lesion or complaint of the somatosensory nervous system, (2) to distinguish the NP element from nociceptive pain, and (3) to distinguish the NP element from nociplastic pain.


Neuropathic pain may affect from a broad range of different neurological diseases affecting the supplemental or the central nervous system. Habitual pain may also do in neurological conditions of unknown etiology, i.e., idiopathic neuropathies. Still, not all cases affected by neural diseases or lesions do develop NP. Extent and inflexibility of NP vary markedly between cases suffering from the same beginning complaint or neural lesions, particularly in diabetic polyneuropathy (dPNP). Whether or not cases develop NP seems to be a multifactorial commerce of psychosocial, inheritable, natural, and clinical threat factors. A large (actors), presently running multi-center experimental study, DOLORisk, aims to interpret these threat factors of development of NP.


Habitual NP constantly causes major suffering, a reduced quality of life and disability in cases, and is a major factor contributing to the global burden of complaint. For the general population, a frequence of NP of6.9 – 10 is estimated. The frequence of NP is likely to increase as we’re facing, among other threat factors, a growing population, adding rotundity rates and an increase in survival of cancer cases that may suffer from sequelae of chemotherapeutics. Still, methodical enrollment of prevalence and frequence of NP in the general population is delicate because the current performances of the International Bracket of Disease (ICD-9 or ICD-10) are concentrated on the underpinning lesions or conditions and not on whether or not they’re painful. Similar data have only been attained by devoted checks in certain countries or for certain etiologies. Generally, the association of pain and the underpinning neurological complaint is largely variable. While in some conditions similar as postherpetic neuralgia or trigeminal neuralgia, pain is the most prominent incarnation, in others similar as chemotherapy- convinced neuropathy or dPNP, it may do only in a group of cases. Indeed among cases with the same underpinning cause of NP, painful symptoms and signs may differ depending on the studied population, the individual tools or criteria.

Given the adding frequence of diabetes mellitus (DM) worldwide, dPNP is and will be one of the most important and common causes of NP. In 2000, 171 million (2.8 of the world population) people suffered from DM, protrusions at the time for 2030 of 366 million (4.4) are formerly in far surpassed. Moment, in 2019, 425 million (8.6) are affected; in 2045 629 million (9.8) people are anticipated with DM worldwide (IDF Diabetes Atlas; United Nations (2019) Modification of World Population Prospects) dPNP is a frequent complication of long- term diabetes and one of the leading causes of morbidity and disability. While over to 60 in cases with habitual DM are affected by dPNP, formerly in recently diagnosed cases, 7 – 10 suffer from neuropathy. It seems to be generally more current in Europeans as compared with Asians. In dPNP, NP is one of the main symptoms. Substantially, cases suffering from pDN are regarded as a group of dPNP cases (≤ 60). Still, in one-fourth of all DM cases, painful symptoms do without any other signs of neuropathy. Of all DM cases, 20 – 50 suffer from pDN.

The burden of complaint in pDN is much advanced than in other habitual pain conditions performing in reduced health- related quality of life comorbidities, similar as sleep diseases, anxiety/depression and cardiovascular conditions, and “severe” pain in further than half of the affected cases. Indeed 10- time mortality is advanced in cases suffering from pDN than in cases without pain.

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