Journal of Spine & NeurosurgeryISSN: 2325-9701

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Research Article, J Spine Neurosurg Vol: 5 Issue: 4

Pediatric Ependymoma: Molecular Characteristics and Useful Prognostic Markers

Pérez-Ramírez M1,4, García-Méndez A2, de León FCP3, Fabio Salamanca-Gómez A1 and García-Hernández N1*
1Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría“Dr. Silvestre Frenk Freud”, Centro Médico Nacional “Siglo XXI”, IMSS. Av. Cuauhtémoc 330, Col. Doctores, 06720, Del. Cuauhtémoc, México
2Servicio de Neurocirugía Pediátrica, Hospital General “Dr. Gaudencio González Garza”, Centro Médico Nacional “La Raza”, IMSS. Calzada Vallejo y Jacarandas S/N 02980 Col. La Raza, Del. Azcapotzalco, México
3Departamento de Neurocirugía, Hospital Infantil de México “Federico Gómez”. Dr. Márquez 162, Col. Doctores, 06720, Del. Cuauhtémoc, México
4Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México. Avenida Ciudad Universitaria 3000, 04360, Coyoacán, México
Corresponding author : Dr. Normand Garcia-Hernandez
Medical Research Unit in Human Genetics, Pediatric Hospital, CMN S-XXI, IMSS, Mexico City, Mexico
Tel: [52] (55) 56276900 ext. 21941
Fax: [52] (55) 55885174
E-mail: [email protected]
Received: May 10, 2016 Accepted: June 28, 2016 Published: July 10, 2016
Citation: Pérez-Ramírez M, García-Méndez A, de León FCP, Salamanca-Gómez FA, García-Hernández N (2016) Pediatric Ependymoma: Molecular Characteristics and Useful Prognostic Markers. J Spine Neurosurg 5:4. doi:10.4172/2325-9701.1000223

Abstract

Ependymoma is a type of brain tumor that originates from ependymal cells in the ventricular system of the brain and the central canal of the spinal cord. Ependymoma tumors remain a public health concern. Over the last several decades, ependymoma tumors have been studied at the molecular level. In pediatric ependymomas, deletions of chromosomes 6q and 22q as well as the amplification of chromosome 1q have been observed. The MMP2, MMP14, PI3K, and MGMT genes have been proposed to be prognostic markers of ependymoma. At the epigenetic level, medullary ependymoma has a different methylation pattern from intracranial EP. The EZH2 and MGMT genes play an important role in cell cycle-related gene expression.

Keywords: Pediatric ependymoma; Characterization; Therapeutic target

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