Journal of Virology & Antiviral ResearchISSN: 2324-8955

Research Article, J Virol Antivir Res Vol: 6 Issue: 3

Profiles of Hepatitis B Virus Serological Markers among Asymptomatic Population in Anambra State, Southeastern Nigeria

Bakarey AS1, Ifeorah IM2*, Adewumi MO3, Faleye TOC3,4, Akere A5, Omoruyi EC6, Ogunwale AO7, Uttah CC8, Oketade MA4 and Adeniji JA3

1Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.

2Department of Medical Laboratory Sciences, College of Medicine, University of Nigeria Nsukka, Enugu, Nigeria

3Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria

4Department of Microbiology, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria

5Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria

6Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria

7Oyo State College of Agriculture and Technology, Igboora, Nigeria

8Department of Science Laboratory Technology, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria

*Corresponding Author : Ifeorah IM
Department of Medical Laboratory Sciences, College of Medicine, University of Nigeria Nsukka, Enugu, Nigeria
Tel: +2348063845774
E-mail: [email protected]

Received: October 20, 2017 Accepted: November 10, 2017 Published: November 17, 2017

Citation: Bakarey AS, Ifeorah IM, Adewumi MO, Faleye TOC, Akere A, et al. (2017) Profiles of Hepatitis B Virus Serological Markers among Asymptomatic Population in Anambra State, Southeastern Nigeria. J Virol Antivir Res 6:3. doi: 10.4172/2324-8955.1000174

Abstract

Hepatitis B Virus (HBV) infection is apparent in endemic countries affecting millions of people. Further, the asymptomatic nature of the pathogen is a major public health concern. This study was designed to assess the burden of HBV by exploring the serologic markers of infection among consenting asymptomatic community dwellers in two cities in southeastern Nigeria.
A total of 405 blood specimens were tested for HBsAg, anti-HBs, HBeAg, anti-HBe, total anti-HBc and anti-HBc-IgM using ELISA technique. Overall, 14 (3.5%) of the participants had detectable HBsAg out of which 1 (7.1%) had HBeAg and 13, anti-HBe. Two of the HBsAg positives (14.3%) had detectable anti-HBc-IgM. A
total of 144 (35.5%) had detectable anti-HBc, even as 65 (57.0%) of them had the marker as the only serologic evidence of HBV exposure. Thirty-seven (9.1%) participants had anti-HBs only although all of them were born before the start of the childhood HBV vaccination. Altogether, 224 (57.3%) had no detectable serological markers of HBV infection or immunity and were obviously at risk of HBV infection.
This study described various patterns of HBV serologic markers of infection in the study population and probable risk of virus spread. Our results support the need for urgent intervention and implementation of measures to control the spread of HBV infection in Nigeria.

Keywords: HBV; Serological markers; Asymptomatic; Community dwellers; ELISA; Anambra; Nigeria

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