Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Review Article, J Clin Exp Oncol Vol: 6 Issue: 4

Rho-Kinases in Oral Squamous Cell Carcinoma: A Review

Anjali P Ganjre*, Sangamithra S and Asmita Kharche

Department of Oral Pathology and Microbiology, Dr. D.Y Patil Dental College and Hospital, Dr. D.Y Patil Vidyapeeth, Pimpri, Pune 411018 Maharashtra, India

*Corresponding Author : Anjali P Ganjre
Department of Oral Pathology and Microbiology, Dr. D.Y Patil Dental College and Hospital, Dr. D.Y Patil Vidyapeeth, Pimpri, Pune 411018 Maharashtra, India
Tel: 9970722995
E-mail: [email protected]

Received: April 10, 2017 Accepted: April 20, 2017 Published: April 27, 2017

Citation: Ganjre AP, Sangamithra S, Kharche A (2017) Rho-Kinases in Oral Squamous Cell Carcinoma: A Review. J Clin Exp Oncol 6:4. doi: 10.4172/2324-9110.1000189

Abstract

OSCC is most common and lethal malignancy worldwide. Global estimated death is to be more than 10,000 annually. Metastasis is the deadly consequence associated with OSCC because of homing of cancer cells to lymph nodes. Motility of cells is accomplished by important signaling molecule known as Rho kinases. Rhokinases modulates cytoskeleton of ?transformed? malignant cell to govern distant metastasis. Interaction of Rho kinases and signaling molecules assists in driving the tumor cell through extracellular matrix and blood vessels to reach the destined location. By focusing and systemizing on the molecular aspect of Rhokinases will help in divulging the problem of the mobility of OSCC cells and will also aid in designing novel anticancer therapies.

Keywords: Rho-kinases; Oral cancer; Metastasis

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