Journal of Virology & Antiviral ResearchISSN: 2324-8955

Research Article, J Virol Antivir Res Vol: 4 Issue: 3

Prevalence of Viral Hepatitis B and C Markers in Multitransfused Patients with Chronic Kidney DiseaseCompared with The General Population in Albania

Tatjana Nurka1*, Erika Ebranati2, Robert Çina3, Zhaneta Abazi4, Anila Kristo5, Xhensila Frasheri1, Vjollca Shpata1, Pranvera Dragusha6, Massimo Ciccozzi7, Gianguglielmo Zehender2 and Renata Shkjezi6
1Department of Medical and Technical Science, University of Medicine, Tirana, Albania
2Department of Biomedical and Clinical Sciences “L. Sacco”, University of Milan, Italy
3University of Sports of Tirana, Albania
4National Blood Transfusion Centre, Tirana, Albania
5Faculty of Medicine, University of Medicine, Tirana, Albania
6Faculty of Medicine, Catholic University “Our Lady of Good Council”, Tirana, Albania
7Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy
Corresponding author : Tatjana Nurka
University of Medicine, Tirana, Faculty of Medical and Technical Science,Kongresi Manastirit 133,1005, Tirana, Albania
Tel: 00355692073253
E-mail: [email protected]
Received: August 01, 2015 Accepted: September 01, 2015 Published: September 07, 2015
Citation: Nurka T, Ebranati E, Çina R, Abazi Z, Kristo A, et al. (2015) Prevalence of Viral Hepatitis B and C Markers in Multitransfused Patients with Chronic Kidney Disease Compared with The General Population in Albania. J Virol Antivir Res 4:3. doi:10.4172/2324-8955.1000142

Abstract

Objective

Evaluation of the prevalence of viral hepatitis markers in CKD patients and comparison with the prevalence in family replacement donors as a control group of the general population in Albania.

Methods

64 patients with CKD treated with three or more blood transfusions were evaluated for Hepatitis B and C markers. They were divided in hemodialysed (HD) and non-hemodialysed (Non- HD) patients. We compared the prevalence of HBV and HCV markers founded in these patients with those of blood donors group which includes 1993 subjects divided in two categories: regular blood donors 625 subjects and family replacement donors 1368 subjects, the later being considered as control group.

Result

The prevalence of viral hepatitis B and C markers found in CKD patients were significantly higher than those of the control group (27% and 31% vs 8.5% and 2%). There are no significant differences of HBsAg prevalence in HD and Non-HD patients, but there is a significant one in the presence of anti HCV in HD patients. We also assessed the impact of age and temporal duration of hemodialysis in this prevalence. We confirm that the prevalence of HCV and HBV markers is significantly higher in CKD compared to the general Albanian population.

Conclusions

The amount of blood transfusions and the age of patients are important risk factors for the spread of these infections.

Keywords: Chronic kidney disease; Hemodialysed patients; Hepatitis B Virus; Hepatitis C Virus; Blood transfusion; Family replacement donors; Blood donors

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