Cell Biology: Research & TherapyISSN: 2324-9293

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Research Article, Cell Biol Res Ther Vol: 0 Issue: 0

Preventive Effects of Methanolic Extract of Seeds of Nigella sativa Linn. on PMA Induced Apoptosis in Human Blood Lymphocytess

Yamani B Tripathi* and Nidhi Pandey
Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Corresponding author : Yamani B Tripathi
Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Tel: 9415694450
E-mail: [email protected]
Received: February 03, 2015 Accepted: June 08, 2015 Published: June 15, 2015
Citation: Tripathi YB, Pandey N (2015) Preventive Effects of Methanolic Extract of Seeds of Nigella sativa Linn. on PMA Induced Apoptosis in Human Blood Lymphocytes. Cell Biol: Res Ther 4:1. doi:10.4172/2324-9293.1000117

Abstract

Although radiation therapy is widely used for cancer-treatment but it is associated with several side effects. It involves free radical/PKC mediated pathway to induce DNA damage and apoptosis in target cells. The tyrosine kinase inhibitors, antioxidants and PKC inhibitors have been reported to be radio-protective. However, new radio-protector, especially from herbal origin is always in demand, as they have comparatively lesser side effects, because of their natural origin.

Keywords: Nigella sativa seeds; Lymphocytes; Ayurveda; Complementary and alternative medicine (CAM); Antioxidant; PMA, Apoptosis; Comet assay; Herbals

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