A study to compare efficacy of metformin-glimepiride versus metformin-tenelig liptinin type II diabetic patients

<p>Md Gayoor khan and Umama Yezdani</p>

A study to compare efficacy of metformin-glimepiride versus metformin-tenelig liptinin type II diabetic patients

Md Gayoor khan and Umama Yezdani

Truba institute of Pharmacy Bhopal Madhya Pradesh, India

: J Addict Behav Ther Rehabil

Abstract

Diabetes mellitus relates a metabolic disorder of collective aetiology which is characterized by chronic hyperglycaemia caused due to disturbances of carbohydrate, lipid and protein metabolism due to the impaired β cell function of the pancreas or insulin résistance or both. Biguanides and Sulphonylureas are the most commonly prescribed drugs due to their efficacy And safety. A total of 60 patients were enclosed in the present study who met the inclusion criteria. They were divided into two groups based on their treatment plan-GroupA and GroupB. The GroupB(P=0.001)exhibited a significantly greater reduction in HbA1c as compared to GroupA(P=0.002). The reduction sinFPG and PPG were also found to be significantly more in The GroupB. In the present study, we observed that patients on Metformin-Teneligliptin Exhibited better control over glycemic profile as well as lipid profile when compared to patients who are on Metformin Glimepiride combination. Since this study was conducted in less number of patients, to make consecutive remarks about the superiority of either of the treatment regimen, furthermore analysis of clinical trials required for appropriate selection of the best combination of anti-diabetic medication.