Journal of Traumatic Stress Disorders & Treatment ISSN: 2324-8947

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Antidepressant-like effects of Crataegus pinnatifida extract on the immobility behavior of mice in the forced swim and tail suspension tests


Chang-Ho Lee, Hyun-Jung Son, Dong-wook Lim and Daeseok Han

Korea Food Research Institute, Korea

: J Trauma Stress Disor

Abstract


Hawthorn (also known as Crataegus pinnatifida which is the fruit of Crataegus species) is commonly used in Chinese herbs to reduce risk of cardiovascular diseases such as heart failure, arrhythmias and hypertension. Many studies have reported that extracts from the fruits of C. pinnatifida have beneficial effects on the cardiovascular system including cardiovascular protection, improvement of coronary circulation and hypolipidemic effects. Here, we aimed to determine whether C. pinnatifida extracts exhibited antidepressant-like activity in mice subjected to forced swim (FST) and tail suspension (TST) tests-induced depression. Acute treatment of mice with C. pinnatifida extracts (300 mg/kg, p.o.) significantly reduced immobility time and increased swimming time without any significant change in climbing. In addition, C. pinnatifida extracts, at concentrations that were not affected by cell viability, significantly prevented the dexamethasone (DEX)-induced decreases in cell viability by an 3-[4,5 dimethylthiazol-2-yl]-2,5- diphenyl-tetrazolium bromide (MTT) assay using SH-SY5Y human neuroblastoma cell. In our results determined that C. pinnatifida extracts may have biological effects on neuroprotection and exhibited significant antidepressant-like effects in the FST and TST. Therefore our finding suggests that C. pinnatifida extracts has preventive or therapeutic potential for the treatment of depressionrelated disorders. Keywords: Crataegus pinnatifida, Antidepressant activity, SH-SY5Y cells, Behavioral tests

Biography


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