Endocrinology & Diabetes ResearchISSN: 2470-7570

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Diabetes does not increase the risk of hospitalization due to COVID-19 in patients aged 50 years or older in primary care-APHOSDIAB-COVID-19 multicenter study

Ana M. Cebrian-Cuenca

Biomedical Research Institute of Murcia, Spain

: Endocrinol Diabetes Res


The purpose of this study was to identify clinical, analytical, and sociodemographic variables associated with the need for hospital admission in people over 50 years infected with SARS-CoV-2 and to assess whether diabetes mellitus conditions the risk of hospitalization. A multicenter casecontrol study analyzing electronic medical records in patients with COVID-19 from 1 March 2020 to 30 April 2021 was conducted. We included 790 patients: 295 cases admitted to the hospital and 495 controls. Under half (n = 386, 48.8%) were women, and 8.5% were active smokers. The main comorbidities were hypertension (50.5%), dyslipidemia, obesity, and diabetes (37.5%). Multivariable logistic regression showed that hospital admission was associated with age above 65 years (OR from 2.45 to 3.89, ascending with age group); male sex (OR 2.15, 95% CI 1.47–3.15), fever (OR 4.31, 95% CI 2.87–6.47), cough (OR 1.89, 95% CI 1.28–2.80), asthenia/malaise (OR 2.04, 95% CI 1.38–3.03), dyspnea (4.69, 95% CI 3.00–7.33), confusion (OR 8.87, 95% CI 1.68–46.78), and a history of hypertension (OR 1.61, 95% CI 1.08–2.41) or immunosuppression (OR 4.97, 95% CI 1.45–17.09). Diabetes was not associated with increased risk of hospital admission (OR 1.18, 95% CI 0.80–1.72; p = 0.38). Diabetes did not increase the risk of hospital admission in people over 50 years old, but advanced age, male sex, fever, cough, asthenia, dyspnea/confusion, and hypertension or immunosuppression did.


Degree in Medicine and Surgery from the University of Valencia, Doctor of Medicine from the University of Valencia with cum laude qualification, Member of the Executive Committee of PCDE-Primare Care Diabetes Europe, University Professor at UCAM and at Miguel Hernández University in Elche , Lecturer, Diabetes Researcher and member of numerous international professional medical societies, such as the Spanish Society of Family Medicine, where she is a member of the Diabetes Research Group, of the Spanish Diabetes Association, among others. Passionate of Medicine, research and working with the highest standards of excellence, demand and dedication, in order to apply the cutting edge of science to the day-to-day life of the profession. Author of more than 100 national and international publications, with multiple appearances in both scientific and general newspapers, having received multiple grants and awards.

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