Effectiveness of topical preparations with collagenase in the treatment of post-acne scars

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Kseniya Sorokina and Paskevich P

Ural State Medical University, Russia

: J Plast Surg Cosmetol

Abstract

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Statement of the Problem: Among dermatological pathologies, acne vulgaris is observed in 22.0% - 32.0% of patients. As a result of the regression of elements, in 10–40% of cases, a post-acne symptom complex is formed with the formation of cicatricial deformities on the face and open areas of the skin, which affects the social and psychological functioning of a person, contributing to the development of anxiety-depressive and psychopathological disorders. The purpose of this study is to research the effectiveness of a topical agent containing collagenase in the treatment of atrophic post-acne scars. Methodology & Theoretical Orientation: The clinical longitudinal uncontrolled study (before-after study) was conducted. Evaluation of the effectiveness of post-acne scar treatment was carried out using the «A Qualitative Global Scarring Grading System» (Goodman G.J., Baron J., 2006) and Manchester Scar Scale (MSS). Patients' quality of life was assessed using «The Dermatology Life Quality Index» (DLQI) questionnaire. Findings: As a result of the use of a topical preparation with collagenase in the treatment of atrophic scars for 3 months, a pronounced remodeling effect was obtained (score by G.J. Goodman scale (p<0.05), MSS (p<0.05)). The quality of life of patients and their social adaptation (DLQI p<0.001) were improved due to minimization of clinical manifestations of post-acne atrophic scars. After the course of treatment, 18.1% of patients refused the daily use of concealing agents. Conclusion & Significance: The high efficiency of topical agents with collagenase for the correction of post-acne scars allows treatment as monotherapy in patients of different age categories, as well as use at the stage of preparation or in combination with other methods of treatment of scarring of the skin. References 1. Li D, Chen Q, Liu Y, Liu T, Tang W, Li S (2017) The prevalence of acne in Mainland China: a systematic review and metaanalysis. BMJ Open 7:4. 2. Hayashi N, Miyachi Y, Kawashima M (2015) Prevalence of scars and ‘mini-scars’, and their impact on quality of life in Japanese patients with acne. J Dermatol 42:690-6. 3. Sinonova NV, Ufimtseva MA, Sorokina KN, Zhunisova DS, Mylnikova ES (2021) Modern laser technologies for treatment of atrophic acne scars. Vestnik Ural'skogo gosudarstvennogo meditsinskogo universiteta 4:55:46-49. 4. Goodman GJ (2006) Postacne scarring: a qualitative global scarring grading system. Dermatologic Surgery 32:12:1458- 1466. 5. Finlay AY, Khan GK (1994) Dermatology Life Quality Index (DLQI): A simple practical measure for routine clinical use. Clinical and Experimental Dermatology 19:210-216. 6. Tan JK, Tang J, Fung K, Gupta AK, Richard Thomas D, Sapra S, Lynde C, Poulin Y, Gulliver W, Sebaldt RJ (2010) Development and validation of a Scale for Acne Scar Severity (SCAR-S) of the face and trunk. J Cutan Med Surg 14:156-160. 7. Sorokina KN, Ufimtseva MA, Simonova NV, Beresneva TA, Paskevich PV (2022) Topical enzymatic therapy of atrophic acne scars. Klinicheskaya Dermatologiya i Venerologiya. 21(6):840 848

Biography

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Sorokina Kseniya PhD, Associate Professor at the Department of dermatovenerology and life safety, dermatovenereologist, cosmetologist. Member of the international society of experts SkinAlliance, Member of the Russian Society of Clinical Oncology RUSSCO, Member of RHRS. Laureate of the International Prize for Social Responsibility in Dermatology (23rd WCD World Congress of Dermatologists, Canada, Vancouver, 2015). The main scientific areas are pediatric dermatology, dermatooncology, trichology, aesthetic medicine, cell technologies.