Synthesis of ethosomes with methylene blue for transdermal photo cosmetology

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Victor B Loschenov, Arina V Voitovaand and Kanamat T Efendiev

LLC BIOSPEC, Russia

: J Plast Surg Cosmetol

Abstract

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Statement of the problem: One of effective methods of combating dermatological and cosmetological problems is transdermal delivery by ethosomes through skin’s barriers. The obstacles have protective system, which does not allow to penetrate different chemical agents, microorganisms, allergens, ultraviolet radiation. The ethosomes synthesized by us consist of clinically approved drugs: methylene blue, lecithin, ethanol and water. On the one hand, methylene blue is a good antioxidant, on the other hand, it is used for the destruction of scar formations and aged skin areas. The nanocarriers disrupt lipid barrier of intercellular interactions and penetrate in the depth. We synthesized ethosomes in aqueous solution in which methylene blue is released under light exposure. The experiment on human’s skin confirmed obtained results. References 1. Paiva-Santos, A. C., Silva, A. L., Guerra, C., Peixoto, D., Pereira-Silva, M., Zeinali, M., & Veiga, F. (2021). Ethosomes as nanocarriers for the development of skin delivery formulations. Pharmaceutical Research, 38(6), 947-970. 2. Godin, B., & Touitou, E. (2003). Ethosomes: new prospects in transdermal delivery. Critical Reviews™ in Therapeutic Drug Carrier Systems, 20(1). 3. Yang, L., Wu, L., Wu, D., Shi, D., Wang, T., & Zhu, X. (2017). Mechanism of transdermal permeation promotion of lipophilic drugs by ethosomes. International journal of nanomedicine, 12, 3357.

Biography

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Victor B. Loschenov is professor and head of laboratory at Prokhorov General Physics Institute of Russian Academy of Sciences, professor at National Research Nuclear University (NRNU) MEPhI, Russia. His research interests are focused on fundamentals and practical applications of photodynamic therapy and fluorescent diagnostics of cancer, medical devices, phototheranostics, different modalities of optical spectroscopy. He received the Ph.D. degree in 1981 from N.S. Kurnakov Institute of General and Inorganic Chemistry, Academy of Sciences of the USSR on specialty “Quantum radio physics”. In 2006, he received the degree of doctor of science in Laser Physics from Prokhorov General Physics Institute of Russian Academy of Sciences with subject: “Methods and apparatus for spectral-fluorescence diagnosis and photodynamic therapy”. Since 2007, he has a title of professor in Laser physics. His professional experience includes the position of head of Laser Biospectroscopy Laboratory at GPI RAS (Moscow, Russia) (from 1989 till present) and professor and head of department in NRNU MEPhI, Russia.