The secretion and excretion of maggot (maggot ES) promote wound healing by regulating the differentiation subtype of macrophages

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Tian-Yuan Wang

Air Force Hospital of Eastern Theater Command, China

: Endocrinol Diabetes Res

Abstract

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Objective: To investigate the effect of maggot ES on macrophage subtype differentiation. Methods: Macrophages were treated with ES of different concentrations and time gradients; The marker molecules of macrophage subtypes were detected after harvesting cells. Results: iNOS, TNF-a, IL-1β and IL-6 in macrophages after ES treatment, was highly expressed; The expression of MR and Arg1 was significantly down regulated. Conclusion: Maggot ES can promote the differentiation of macrophages into M1 pro-inflammatory type and inhibit the differentiation into M2 anti-inflammatory type, providing a research basis for the further study of ES in promoting refractory wounds.

Biography

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