Journal of Spine & NeurosurgeryISSN: 2325-9701

Research Article, J Spine Neurosurg Vol: 3 Issue: 6

Prognostic Significance of Immunohistochemical Expression of EGFR, Inos and Ki-M1P in Skull Base Chordoma: A Series of 74 Patients

Akhavan-Sigari R1*, Abili M2, Rohde V1 and Ostertag H3
1Department of Neurosurgery, University Medical Center Göttingen, Georg-August-University Göttingen, Germany
2Department of Neurosurgery, Mashhad University of Medical Sciences, Taleghani Hospital, Mashhad, Iran
3Department of Pathology, Nordstadt Medical Center, Klinikum Hannover, Germany
Corresponding author : Akhavan-Sigari R
University Medical Center Göttingen, Georg-August-University Göttingen, Germany
Tel: +49-551-396033; Fax: +49-551-398794
E-mail: [email protected]
Received: June 24, 2014 Accepted: July 30, 2014 Published: August 04, 2014
Citation: Akhavan-Sigari R, Abili M, Rohde V, Ostertag H (2014) Prognostic Significance of Immunohistochemical Expression of EGFR, Inos and Ki-M1P in Skull Base Chordoma: A Series of 74 Patients. J Spine Neurosurg 3:6 doi:10.4172/2325-9701.1000163

Abstract

 Prognostic Significance of Immunohistochemical Expression of EGFR, Inos and Ki-M1P in Skull Base Chordoma: A Series of 74 Patients

To investigate the expression of epidermal growth factor receptor (EGFR), inducible nitric oxide synthase iNOS and Ki-M1P in skull base chordoma. To the authors’ knowledge, little is known regarding the prognostic significance of receptor tyrosine kinase and role of iNOS expressed by macrophages in chordoma induced inflammation and tumor progression of skull base chordoma.

Keywords: Chordoma; EGFR; iNOS; Monocytes/Macrophages marker; Skull base

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