Journal of Molecular Medicine & Therapeutics#

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Editorial, Mol Med Ther Vol: 1 Issue: 1

Prolyl Hydroxylases in fight or flight

Anne-Theres Henze1,2, Rodrigo Leite de Oliveira1,2 and Massimiliano Mazzone1,2*
1Lab of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium
2Lab of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, KU Leuven, Leuven, Belgium
Corresponding author : Dr. Massimiliano Mazzone
Vesalius Research Center, VIB, KU Leuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium
Tel: +32-16-37.32.13
E-mail: [email protected]
Received: July 28, 2012 Accepted: July 31, 2012 Published: August 11, 2012
Citation: Henze AT, Leite de Oliveira R, Mazzone M (2012) Prolyl Hydroxylases in fight or flight. Mol Med Ther 1:1 doi:10.4172/2324-8769.1000e102

Abstract

Prolyl Hydroxylases in fight or flight

The fight or flight response was introduced by the American physiologist Walter Bradford Cannon at the beginning of the 20th century as a primary instinctive reaction of animals to a situation of danger. Applying this simplified point of view from behavioral research to studies of the cellular response to stress signals we are able to narrow down the complexity of the cellular system to either evading (“fleeing”) or resisting (“fighting”) growth-restricting conditions. We believe that the prolyl hydroxylase domain (PHDs) proteins function at important crossroads between these two extremes.

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