Review Article, Mol Med Ther Vol: 1 Issue: 1
Regulation of Coronary Vasomotor Function by Reactive Oxygen Species
| Lih Kuo*, Naris Thengchaisri and Travis W. Hein |
| Departments of Systems Biology & Translational Medicine, Ophthalmology and Surgery, College of Medicine, Texas A&M Health Science Center, Temple, Texas 76504, USA |
| Corresponding author : Lih Kuo Professor and Kruse Family Centennial Chair, Department of Systems Biology and Translational Medicine, College of Medicine, Texas A&M Health Science Center, 702 Southwest H.K. Dodgen Loop, Temple, Texas 76504, USA Tel: 254-742-7032; Fax: 254-742-7145 E-mail: [email protected] |
| Received: July 14, 2012 Accepted: July 30, 2012 Published: August 08, 2012 |
| Citation: Kuo L, Thengchaisri N, Hein TW (2012) Regulation of Coronary Vasomotor Function by Reactive Oxygen Species. Mol Med Ther 1:1. doi:10.4172/2324-8769.1000101 |
Abstract
Regulation of Coronary Vasomotor Function by Reactive Oxygen Species
Overproduction of reactive oxygen species is closely associated with cardiovascular diseases in partby impairing endothelial function and consequently compromising blood flow regulation. Superoxide and hydrogen peroxide areelevated under various disease states with reduced endothelium-derived nitric oxide bioavailability. The oxidative stress elicited by angiotensin II, C-reactive protein and tumor necrosis factor-α is mediated by the activation of different redox signaling pathways in the microvasculature. The upregulation of L-arginine consuming enzyme arginase also contributes to the reduced nitric oxide bioavailability during oxidative stress.