Journal of Virology & Antiviral ResearchISSN: 2324-8955

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, J Virol Antivir Res Vol: 2 Issue: 2

Ribavirin has an In vitro Antiviral Effect in Rabies Virus Infected Neuronal Cells but Fails to Provide Benefit in Experimental Rabies in Mice

Camila Michele Appolinário1, Christophe Prehaud2,3, Susan Dora Allendorf1, João Marcelo Azevedo de Paula Antunes1, Marina Gea Peres1, Monique Lafon2,3* and Jane Megid1
1UNESP- School of Veterinary Medicine and Animal Science- Department of Veterinary Hygiene and Public Health, Botucatu, São Paulo, Brazil
2Institut Pasteur- Unité de Neuroimmunologie Virale, Département de Virologie, Paris, France
3CNRS, UMR3569, F-75015 Paris, France
Corresponding author : Monique Lafon
Institut Pasteur- Unité de Neuroimmunologie Virale, Département de Virologie, Paris, France
Tel: +33 1 45 68 87 52; Fax: + 33 1 40 61 33 12
E-mail: [email protected]
Received: April 16, 2013 Accepted: June 24, 2013 Published: June 27, 2013
Citation: Appolinário CM, Prehaud C, Allendorf SD, de Paula Antunes JMA, Peres MG, et al. (2013) Ribavirin has an In vitro Antiviral Effect in Rabies Virus Infected Neuronal Cells but Fails to Provide Benefit in Experimental Rabies in Mice. J Virol Antivir Res 2:2. doi:10.4172/2324-8955.1000111

Abstract

Ribavirin has an In vitro Antiviral Effect in Rabies Virus Infected Neuronal Cells but Fails to Provide Benefit in Experimental Rabies in Mice

The nucleoside analog ribavirin is one of the antiviral drugs recommended in the management of several viral infections in humans. Although ribavirin has been used in rabies treatment, its efficacy has not been formally proven. The objectives were to study the effect of ribavirin on rabies virus (RABV) infection in neuronal cultures, to analyze whether orally-given ribavirin activates an innate immune response in the brain and whether ribavirin confers protection against brain infection in a model of experimental rabies in mice.

Keywords:

Track Your Manuscript

Share This Page

Media Partners