Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Case Report, J Liver Dis Transplant Vol: 3 Issue: 2

RIO Kinase 3 over Expression Promotes Hepatocellular Carcinoma Invasion through Induction of Epithelial- Mesenchymal Transition and a Potential Link to WNT/β-Catenin Pathway Activation

Trina Das1, Sajida Hassan2, Qinghua Feng3, David Gretch2, Jorge D Reyes1 and James D Perkins1*
1Division of Transplantation, Department of Surgery, University of Washington School of Medicine, Seattle, WA, USA
2Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, USA
3Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
Corresponding author : James D Perkins, MD
Professor of Surgery, Director of Clinical and Bio-Analytics Transplant Lab, Division of Transplantation, Department of Surgery, 1959 NE Pacific Street, Box 356410, Seattle, WA 98195-6410, USA
Tel: (206) 543-3825
E-mail: [email protected]
Received: July 07, 2014 Accepted: October 10, 2014 Published: October 15, 2014
Citation: Vidjak V, Novačić K, Ramač JP, Crnčević MG (2014) Endovascular Treatment of Symptomatic Intrahepatic Portosystemic Venous Shunt Using Amplatzer Vascular Plug II. J Liver: Dis Transplant 3:2. doi:10.4172/2325-9612.1000124

Abstract

RIO Kinase 3 over Expression Promotes Hepatocellular Carcinoma Invasion through Induction of Epithelial-Mesenchymal Transition and a  Potential Link to WNT/β-Catenin Pathway Activation

Recurrence is a major cause of mortality for patients with hepatocellular carcinoma (HCC) following liver transplantation. We previously identified RIOK3 as a prominently expressed gene in HCC tumors that recurred following transplantation. This is consistent with findings of increased RIOK3 expression in metastatic head, neck, and pancreatic cancers, which suggests RIOK3 is involved in cancer recurrence. In this study, we aimed to determine the pathway leading to HCC tumor invasion induced by RIOK3.

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