Journal of Virology & Antiviral ResearchISSN: 2324-8955

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Review Article, J Virol Antivir Res Vol: 1 Issue: 2

Role of Coatomer Protein I in Virus Replication

Jennifer A Thompson and Jay C Brown*
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Corresponding author : Dr. Jay C. Brown
Department of Microbiology, Immunology, and Cancer Biology, Box 800734, University of Virginia Health System, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
Tel: 434-924-1814; Fax: 434-982-1071
E-mail: [email protected]
Received: July 20, 2012 Accepted: September 18, 2012 Published: October 30, 2012
Citation: Thompson JA, Brown JC (2012) Role of Coatomer Protein I in Virus Replication. J Virol Antivir Res 1:2. doi:10.4172/2324-8955.1000102

Abstract

Role of Coatomer Protein I in Virus Replication

Coatomer protein I (COPI) is well known as the protein coat surrounding vesicles involved in returning endoplasmic reticulum (ER)-resident proteins to the ER. COPI coats are also found in vesicles involved in other trafficking processes including endocytosis, autophagy and anterograde transport in the secretory pathway. In view of the diverse functions of COPI proteins, it is expected that they will affect virus replication, and many reports of such COPI involvement have now appeared. The experimental approaches most often employ specific siRNA to deplete COPI subunits or brefeldin A to block COPI activation.

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