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Journal of Spine & NeurosurgeryISSN: 2325-9701

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Review Article, J Spine Neurosurg S Vol: 0 Issue: 0

Role of IL-17 in Glioma Progression

Prahlad Parajuli* and Sandeep Mittal
Department of Neurosurgery, Wayne State University and Karmanos Cancer Institute, Detroit, USA
Corresponding author : Prahlad Parajuli
Department of Neurosurgery, 550 E. Canfield, Lande Bldg #460, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA
Tel: (313) 577-6377
E-mail: [email protected]
Received: June 02, 2013 Accepted: October 14, 2013 Published: October 18, 2013
Citation: Parajuli P, Mittal M (2013) Role of IL-17 in Glioma Progression. J Spine Neurosurg S1. doi:10.4172/2325-9701.S1-004

Abstract

Role of IL-17 in Glioma Progression

There is increasing evidence in the literature pointing to an important role of inflammation during initiation and progression of cancer. Glioblastoma is the most common malignant primary brain tumor with approximately 23,000 newly-diagnosed cases each year in the United States, and has a dismal median survival of only 15 months. Although the blood-brain barrier maintains an immuneprivileged status of the brain under steady state, intracranial tumors including gliomas are invariably infiltrated with various types of immune cells.

Keywords: Malignant glioma; Th17; IL-17; Inflammation; Brain cancer; T cells

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