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Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Review Article, J Liver Dis Transplant Vol: 3 Issue: 2

Sexual Dysfunction in Males with End-Stage Liver Disease: Partial Recovery after Liver Transplantation

Julio CU Coelho*, Alexandre CT de Freitas, Jorge EF Matias, Alcindo Pissaia Jr, José L de Godoy and João OV Zeni
Department of Surgery of the Federal University of Parana, Curitiba, Brazil
Corresponding author : Julio Coelho, MD, PhD
Rua Bento Viana, 1140- Ap 2202, 80240-110 – Curitiba (PR), Brazil
Tel/Fax: 55-41-3322-3789; E-mail: [email protected]
Received: July 14, 2014 Accepted: October 09, 2014 Published: October 13, 2014
Citation: Coelho JCU, Freitas ACD, Matias JEF, Pissaia AJr, Godoy JL, et al (2014) Sexual Dysfunction in Males with End-Stage Liver Disease: Partial Recovery after Liver Transplantation J Liver:: Dis Transplant 3:2. doi:10.4172/2325-9612.1000122

Abstract

Sexual Dysfunction in Males with End-Stage Liver Disease: Partial Recovery after Liver Transplantation

Sexual dysfunction occurs in 70% to 89% of males with end-stage liver disease and reduces significantly the quality of life of the patient and his partner. The pathogenesis is multifactorial and includes hypothalamic-pituitary-gonadal axis dysfunction, psychological stress, associated diseases and use of medications. Hypogonadism is more pronounced in patients with alcoholic cirrhosis and primary hemochromatosis. Sexual dysfunction correlates with the intensity of hepatic dysfunction and is more pronounced in patients with higher Child-Pugh or MELD scores. Although successful liver transplant may improve erectile function and libido, sexual dysfunction frequently persists in many patients. Additional risk factors such as diabetes, arterial hypertension, smoking, alcohol intake, and psychological stress should be identified and adequately treated in order to reduce sexual dysfunction.

Keywords: Liver transplantation; Quality of life; Sexual dysfunction;Hemochromatosis; Hypogonadism; Testosterone; Alcoholic cirrhosis

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