Cell Biology: Research & TherapyISSN: 2324-9293

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Special Issue Article, Cell Biol Res Ther S Vol: 0 Issue: 0

Signalling Pathways in Glioma-Propagating Cells

Lynnette Wei-Hsien Koh1, Tan Boon Toh1, Yuk Kien Chong1,2, Edwin Sandanaraj1,3, Beng Ti Ang2,3,5,6 and Carol Tang1,4,5*
1Department of Research, National Neuroscience Institute, Singapore
2Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
3Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore
4Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore
5Duke-National University of Singapore Graduate Medical School, Singapore
6Department of Neurosurgery, National Neuroscience Institute, Singapore
Corresponding author : C.S.L. Tang
Department of Research, National Neuroscience Institute, Singapore
Tel: 65-6357-7634; Fax: 65-6256-9178
Email: [email protected]
Received: May 27, 2013 Accepted: January 15, 2014 Published: January 20, 2014
Citation: Koh LWH, Toh TB, Chong YK, Sandanaraj E, Ang BT(2014) Signalling Pathways in Glioma-Propagating Cells. Cell Biol: Res Ther S1:003 doi:10.4172/2324-9293.S1-003

Abstract

Signalling Pathways in Glioma-Propagating Cells

TGlioblastomas (GBMs) are highly aggressive and malignant brain tumors and have poor prognosis despite advanced surgical resections accompanied by chemo-radiation interventions.Current therapeutic advances remain essentially palliative, with modest amelioration in clinical response, due largely to the acquired resistance of GBM cells to conventional chemoradiation therapies. The cellular and molecular heterogeneity of GBMs highlights a complex interplay of individual mechanisms that contribute to varied patient treatment response.

Keywords: Cancer stem cell; Glioma; Glioma-propagating cell; Brain tumor

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