Journal of Spine & NeurosurgeryISSN: 2325-9701

Research Article, J Spine Neurosurg Vol: 2 Issue: 3

Spinal Cord Injury-Induced Discharges Modify the Function of Glutamatergic System and Improve Ground and Skilled Locomotor Control

Zaghloul Ahmed1,3*, Ahmed Hawash3 and Andrzej Wieraszko2,3
1Department of Physical Therapy, The College of Staten Island, Staten Island, NY 10314, and Graduate Center/The City University of New York, New York, NY 10016, USA
2 Department of Biology, The College of Staten Island, Staten Island, NY 10314, and Graduate Center/The City University of New York, New York, NY 10016, USA
3The Center for Developmental Neuroscience, The College of Staten Island, Staten Island, New York, NY 10314, USA

Corresponding author : Zaghloul Ahmed
Associate Professor, Department of Physical Therapy, 2800 Victory Boulevard, Staten Island, NY10314, USA
E-mail: [email protected]

Received: February 22, 2013 Accepted: June 20, 2013 Published: June 24, 2013
Citation: Ahmed Z, Hawash A, Wieraszko A (2013) Spinal Cord Injury-Induced Discharges Modify the Function of Glutamatergic System and Improve Ground and Skilled Locomotor Control. J Spine Neurosurg 2:3. doi:10.4172/2325-9701.1000115

Abstract

Spinal Cord Injury-Induced Discharges Modify the Function of Glutamatergic System and Improve Ground and Skilled Locomotor Control

The injury of the spinal cord evokes intense neuronal activity of the spinal neurons. It has been always assumed that this excessive activity, correlated with a massive release of excitatory neurotransmitter, glutamate would impair functional recovery. This assumption constituted a base for developing many pharmacological treatments for acute spinal cord injury (SCI) aimed at reduction of this hyperactivity.

Keywords: Spinal cord; Injury-induced activity; Recovery; Lidocaine; Plasticity;Glutamate; Behaviour

Track Your Manuscript

Share This Page